Navegando por Palavras-chave "orelha/toxicidade"

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    Terapia com células-tronco mesenquimais em modelo animal de ototoxicidade por canamicina
    (Universidade Federal de São Paulo (UNIFESP), 2014-10-31) Barros, Bruno Borges de Carvalho [UNIFESP]; Porcionatto, Marimelia Porcionatto [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Purpose: To evaluate the effect of MSC transplantation on hearing recovery in an animal model of ototoxicity. Methods: Experimental study with 20 adult mice C57 / BL6 submitted to kanamycin + furosemide hearing injury. After 24 hours of injury, mesenchymal stem cells (MSC) that express green fluorescent protein (GFP) were transplanted by transtympanic approach in 10 animals (Injury + MSC). The others animals received only DMEM (Injury). Auditory brainstem response (ABR) tresholds were obtained before injury and two weeks after treatment. Results: Hearing thresholds in group injury + MSC were statistically better than in the injury group. MSCs GFP + were identified by immunohistochemistry in sections of the inner ear. Conclusions: Transtympanic MSC therapy showed statistically better hearing thresholds, suggesting a protective effect against the ototoxic effects caused by AGs. We also noted the ability of these cells to cross the membrane of oval window under stimulus of ototoxic injury