Navegando por Palavras-chave "oxytocin"

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    Induction of Labor using Misoprostol in a Tertiary Hospital in the Southeast of Brazil
    (Federacao Brasileira Soc Ginecologia & Obstetricia-Febrasgo, 2017) Godoy Silva, Tacito Augusto; Borges Junior, Luciano Eliziario; Tahan, Luisa Almeida; Arantes Costa, Taynna Ferreira; Magalhaes, Fernanda Oliveira; Peixoto, Alberto Borges; Martins, Wellington de Paula; Araujo Junior, Edward [UNIFESP]
    Purpose To assess cases of labor induction with vaginal 25-mu g tablets of misoprostol and maternal outcomes in a tertiary hospital in southeastern Brazil. Methods This was a retrospective cohort study of 412 pregnant women with indication for labor induction. Labor induction was performed with vaginal 25-mu g tablets ofmisoprostol in pregnant women with Bishop scores < 6. Stepwise regression analysis was used to identify the factors present at the beginning of induction that could be used as predictors of successful labor induction. Results A total of 69% of the pregnant women who underwent labor induction progressed to vaginal delivery, and 31% of the women progressed to cesarean section. One or two misoprostol tablets were used in 244 patients (59.2%). Of the 412 patients, 197 (47.8%) required oxytocin later on in the labor process, after induction with misoprostol. The stepwise regression analysis showed that only Bishop scores of 4 and 5 and previous vaginal delivery were independent factors with statistical significance in the prediction of successful vaginal labor induction (beta = 0.23, p < 0.001, for a Bishop score of 4 and 5, and beta = 0.22, p < 0.001, for previous vaginal delivery). Conclusion Higher Bishop scores and previous vaginal delivery were the best predictors of successful labor induction with vaginal 25-mu g tablets of misoprostol.
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    Quality of oxytocin available in low- and middle-income countries: a systematic review of the literature
    (Wiley-Blackwell, 2016) Torloni, Maria Regina [UNIFESP]; Freitas, Carolina Gomes [UNIFESP]; Kartoglu, U. H.; Gulmezoglu, A. Metin; Widmer, M.
    BackgroundOxytocin is the drug of choice for preventing and treating postpartum haemorrhage, an important cause of maternal death. Oxytocin is widely available in low and middle-income countries (LMIC) but there are concerns about its quality. ObjectiveTo identify, critically appraise and synthesise the findings of studies on the quality of oxytocin available in LMIC. Search strategyWe searched seven electronic databases, without language restriction. Selection criteriaStudies reporting results of tests to assess quality of oxytocin samples from LMIC. Data collection and analysisStudy selection, data extraction and quality assessment were performed in duplicate. Results are presented descriptively. Main resultsThe search identified 2611 unique citations
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    Sensitivity of the Bothrops jararaca snake uterus to oxytocin and acetylcholine
    (Elsevier B.V., 1996-03-01) Abdalla, FMF; Hayashi, H.; Picarelli, Z. P.; Porto, C. S.; Abreu, L. C.; Universidade Federal de São Paulo (UNIFESP); INST BUTANTAN
    The influence of hormones on the uterine smooth muscle sensitivity has been demonstrated in mammals; however in nonmammalian species much remains to be clarified. This study investigated the sensitivity of the snake (Bothrops jararaca) uterus to oxytocin and acetylcholine. the snakes were divided into three experimental groups: snakes with uterine segments weighing less than or equal to 20.00 mg (A), snakes with uterine segments weighing between 20.01 and 35.00 mg (B) and snakes with uterine segments weighing greater than or equal to 35.01 mg (C). the histomorphometric analysis of the uterus showed an increase in the smooth muscle layer thickness in groups B and C, when compared with group A, suggesting different hormonal conditions of the animals. Cumulative concentration-effect curves to oxytocin and acetylcholine were obtained in uteri of the three experimental groups and the pD(2) values determined. the sensitivity of the snake uterus to oxytocin increased in groups B and C (concentration-effect curves shifted to the left and pD(2) values increased) when compared with group A. the concentration effect curves to acetylcholine were biphasic and shifted to the left, suggesting two binding sites (low and high affinity binding sites) in snake uteri of groups B and C. These results suggest that sex steroids may modulate the sensitivity of the snake uterus to oxytocin and acetylcholine.