Navegando por Palavras-chave "probiotics"

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    Microbiota abnormalities and the therapeutic potential of probiotics in the treatment of mood disorders
    (Walter De Gruyter Gmbh, 2017) Rios, Adiel C. [UNIFESP]; Maurya, Pawan Kumar [UNIFESP]; Pedrini, Mariana [UNIFESP]; Zeni-Graiff, Maiara [UNIFESP]; Asevedo, Elson [UNIFESP]; Mansur, Rodrigo B.; Wieck, Andrea; Grassi-Oliveira, Rodrigo; McIntyre, Roger S.; Hayashi, Mirian A. F. [UNIFESP]; Brietzke, Elisa [UNIFESP]
    Major depressive disorder (MDD) and bipolar disorder (BD) are among the leading causes of burden and disability worldwide. Despite intensified research efforts to improve the treatment options and remission rates in mood disorders, no disease modifying treatment exists for these disorders. Accumulating evidence implicates the involvement of the gut microbiota in processes relevant to etiopathology of central nervous system-based disorders. The objective of this article was to critically evaluate the evidence supporting the link between gastrointestinal microbiota and mood disorders and to discuss the potential benefits of using probiotics in the treatment of MDD and BD. The concept of psychobiotics, which is bacterial-based interventions with mental health benefit, is emerging in the field. On the other hand, while probiotics might potentially represent a significant advance, specific roles of microbiota in the pathophysiology of mood disorders still need further investigation along with intervention studies.
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    O papel dos probióticos e prebióticos na prática pediátrica
    (Sociedade Brasileira de Pediatria, 2006-11-01) Morais, Mauro Batista de [UNIFESP]; Jacob, Cristina Miuki Abe [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)
    OBJECTIVE: To review the effects of probiotics and prebiotics in clinical pediatric practice. SOURCES: MEDLINE was searched, especially for articles that addressed their practical application, in the form of reviews, clinical trials and meta-analyses. Articles that had already been analyzed by the authors were also included. SUMMARY OF THE FINDINGS: Scientific literature on probiotics and prebiotics has remarkably increased in the last 10 years. Their mechanisms of action have been experimentally investigated. Studies indicate that probiotics can act by competing with pathogens, modifying the intestinal environment by reduction in pH, as a result of fermentation products, interacting and modulating local and systemic inflammatory and immune response, among others. Clinical trials and meta-analyses show that probiotics seem to contribute towards the prevention of acute diarrhea and of antibiotic-associated diarrhea, in addition to shortening the duration of acute diarrhea. However, the data are inconsistent and there are no studies confirming their efficacy in terms of cost-benefit ratio. Preliminary studies show that probiotics in early life can reduce the occurrence of atopic dermatitis. The addition of prebiotics to infant formulas is associated with the change in the profile of the intestinal microbiota compared to infants fed milk formulas without prebiotics. CONCLUSIONS: Evidence indicates that new studies should be carried out about probiotics, prebiotics and symbiotics. The specific clinical effects that each probiotic or prebiotic may cause must be considered.
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    Prebióticos, probióticos e simbióticos na prevenção e tratamento das doenças alérgicas
    (Sociedade de Pediatria de São Paulo, 2010-03-01) Souza, Fabíola Suano [UNIFESP]; Cocco, Renata Rodrigues [UNIFESP]; Sarni, Roseli Oselka Saccardo [UNIFESP]; Mallozi, Marcia Carvalho [UNIFESP]; Solé, Dirceu [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Fundação Faculdade de Medicina do ABC Disciplina de Pediatria
    OBJECTIVE: To review current evidence about the effects of probiotics, prebiotics and symbiotics on the immune development as well as on the prevention of allergic diseases in children. DATA SOURCES: Randomized, double-blind clinical trials in humans published in the last five years, in the Medline database, containing the following keywords: prebiotics (oligosaccharides), probiotics, symbiotics and hypersensitivity. DATA SYNTHESIS: For this review three papers with prebiotics were included, all of them using a mixture of GOS:FOS (9:1) in infant formula for the first months of life; 24 papers with probiotics, where L. rhamnosus GG, B. lactis, L. casei, L. paracasei, L. reuteri, L. acidophilus, B. longum, B. breve and P. freudenreichii sp. were the tested bacterial strains; and two papers about symbiotics. CONCLUSIONS: Although there are some evidence of benefits of early supplementation with some specific probiotic strains, prebiotics and symbiotics for the prevention of atopic eczema in children with high risk of allergy development, and probiotic use for the treatment of IgE-mediated moderate and severe atopic dermatitis, further research is needed in order to extended the evaluation of supplemented individuals, safety aspects and long term effects