Navegando por Palavras-chave "repetitive transcranial magnetic stimulation"

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    Repetitive transcranial magnetic stimulation reduces cortisol concentrations in bulimic disorders
    (Cambridge Univ Press, 2011-06-01) Claudino, A. M. [UNIFESP]; Van den Eynde, F.; Stahl, D.; Dew, T.; Andiappan, M.; Kalthoff, J.; Schmidt, U.; Campbell, I. C.; Kings Coll London; Universidade Federal de São Paulo (UNIFESP); Kings Coll NHS Trust
    Background. in people with bulimic eating disorders, exposure to high-calorie foods can result in increases in food craving, raised subjective stress and salivary cortisol concentrations. This cue-induced food craving can be reduced by repetitive transcranial magnetic stimulation (rTMS). We investigated whether rTMS has a similar effect on salivary cortisol concentrations, a measure of hypothalamic-pituitary-adrenal axis (HPAA) activity.Method. We enrolled twenty-two female participants who took part in a double-blind randomized sham-controlled trial on the effects of rTMS on food craving. Per group, eleven participants were randomized to the real or sham rTMS condition. the intervention consisted of one session of high-frequency rTMS delivered to the left dorsolateral prefrontal cortex (DLPFC). Salivary cortisol concentrations were assessed at four time points throughout the 90-min trial. To investigate differences in post-rTMS concentrations between the real and sham rTMS groups, a random-effects model including the pre-rTMS cortisol concentrations as covariates was used.Results. Salivary cortisol concentrations following real rTMS were significantly lower compared with those following sham rTMS. in this sample, there was also a trend for real rTMS to reduce food craving more than sham rTMS.Conclusions. These results suggest that rTMS applied to the left DLPFC alters HPAA activity in people with a bulimic disorder.
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    Repetitive Transcranial Magnetic Stimulation Reduces Cue-Induced Food Craving in Bulimic Disorders
    (Elsevier B.V., 2010-04-15) Van den Eynde, Frederique; Claudino, Angelica M. [UNIFESP]; Mogg, Andrew; Horrell, Linda; Stahl, Daniel; Ribeiro, Wagner [UNIFESP]; Uher, Rudolf; Campbell, Iain; Schmidt, Ulrike; Kings Coll London; Universidade Federal de São Paulo (UNIFESP)
    Background: Craving or the urge to consume is a characteristic of bulimic eating disorders and addictions. Dysfunction of the dorsolateral prefrontal cortex (DLPFC) is associated with craving. We investigated whether stimulation of the DLPFC reduces food craving in people with a bulimic-type eating disorder.Methods: Thirty-eight people with bulimic-type eating disorders were randomly allocated to receive one session of real or sham high-frequency repetitive transcranial magnetic stimulation (rTMS) to the left DLPFC in a double-blind procedure. Outcome measures included self-reported food craving immediately after the stimulation session and frequency of bingeing over a 24-hour follow-up period.Results: Compared with sham control, real rTMS was associated with decreased self-reported urge to eat and fewer binge-eating episodes over the 24 hours following stimulation.Conclusions: High-frequency rTMS of the left DLPFC lowers cue-induced food cravings in people with a bulimic eating disorder and may reduce binge eating. These results provide a rationale for exploring rTMS as a treatment for bulimic eating disorders.