Navegando por Palavras-chave "sarcopenia"
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- ItemSomente MetadadadosDietary Protein Intake in Elderly Women: Association With Muscle and Bone Mass(Sage Publications Inc, 2015-04-01) Genaro, Patricia de Souza; Pinheiro, Marcelo de Medeiros [UNIFESP]; Szejnfeld, Vera Lucia [UNIFESP]; Martini, Ligia Araujo; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)Background: An inadequate food intake, mainly with regard to protein intake, seems to contribute to a reduction of skeletal muscle and bone mass in the elderly. This study was undertaken to evaluate differences in protein intake in women with or without sarcopenia and verify the intake level that is related to a better bone and muscle mass. Methods: Elderly women older than 65 years with sarcopenia (n = 35) and without sarcopenia (n = 165) participated in the study. Assessment of bone mineral density of the lumbar spine and femur was taken, body composition was evaluated by dual-energy x-ray absorptiometry, and an evaluation of protein intake was performed through 3-day dietary records. Results: Muscle, bone, and fat mass was significantly higher in women who had protein intake > 1.2 g/kg/d. A lower intake of essential amino acids in women with sarcopenia was also observed. Protein and energy intake were significant predictors of muscle mass. the presence of osteoporosis was a predictor of muscle strength. in conclusion, the present study demonstrated that in elderly women, an adequate protein intake in terms of quality and quantity, without need of supplementation, could have a positive impact on bone mineral density, lean mass, and skeletal muscle mass.
- ItemSomente MetadadadosThe relationship between lean mass, muscle strength and physical ability in independent healthy elderly women from the community(Springer, 2014-05-01) Pisciottano, M. V. C. [UNIFESP]; Pinto, S. S.; Szejnfeld, V. L. [UNIFESP]; Castro, C. H. M. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Univ Cidade São PauloThe association between muscle mass, strength and physical performance has been established in the elderly with co-morbidities. in this study, lean and fat mass, bone mineral density, knee extension and flexion strength and physical ability tests in healthy independent elderly women were investigated. Main determinants of lean mass, strength and physical ability were determined searching for predictors of healthy aging.A total of 100 healthy women aged a parts per thousand yen 65 years considered independent and active were invited. Bone mass and body composition were assessed by DXA. the strength of the lower limb was assessed by isokinetic dynamometry, and physical ability was measured by: Timed Up and Go (TUG), Berg Balance Test (BBT) and Dynamic Gait Index (DGI).Women were on average 70.8 +/- 4.92 years old, had BMI of 27.38 +/- 5.11 kg/m2 and fat mass of 26.96 +/- 9.62 kg or 40.65 +/- 8.06%. Total lean mass and appendicular lean mass (ALM) were 35.38 +/- 4.83 kg and 15.32 +/- 2.26 kg, respectively, while relative skeletal mass index (RSMI) was 6.51 +/- 0.77 kg/m2. Age did not correlate significantly with ALM. Age and ALM were the main determinants of the strength of the lower limb (p < 0.001) while age and strength of the lower limb were significantly associated with the performance on the physical tests (p < 0.001).Age has a negative impact on the strength and the physical performance in independent healthy women without co-morbidities. Physical ability tests are positively influenced by the strength of the lower limb. These relationships suggest that muscle strength should be the parameter to be prioritized when preparing for healthy aging.
- ItemAcesso aberto (Open Access)Sarcopenia associada ao envelhecimento: aspectos etiológicos e opções terapêuticas(Sociedade Brasileira de Reumatologia, 2006-12-01) Silva, Tatiana Alves de Araujo [UNIFESP]; Frisoli Junior, Alberto [UNIFESP]; Pinheiro, Marcelo de Medeiros [UNIFESP]; Szejnfeld, Vera Lucia [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)The high prevalence of inability and functional dependence is an important problem in elderly people. It is closely related with aging decrease of lean muscle mass that occurs even in healthy subjects. Skeletal muscle mass deficiency, or sarcopenia, results from complex interactions between innervations disturbances, hormones deficiency, inflammatory cytokines and restriction in caloric-proteic ingestion. Loss of skeletal muscle mass and strength results in disability and functional dependency that are associated to frailty in many elderly people. These conditions represent enormous economic and social budget. In this article, we evaluate pathogenesis of sarcopenia and discuss potential therapies.
- ItemSomente MetadadadosSarcopenia, em pacientes com doença renal crônica: prevalência e associação com mortalidade(Universidade Federal de São Paulo (UNIFESP), 2014-09-30) Pereira, Raissa Antunes [UNIFESP]; Kaneko, Maria Ayako Kamimura Kaneko [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Background: In chronic kidney disease (CKD) multiple metabolic and nutritional abnormalities contribute to impairment of skeletal muscle mass and function thus predisposing patients to the condition of sarcopenia. Herein, we investigated the prevalence and mortality predictive power of sarcopenia, defined by three different methods, in non-dialysis-dependent (NDD) CKD patients. Methods: We evaluated 287 NDD-CKD patients stage 3-5 [59.9±10.5 years; 62% men; 49% diabetics; glomerular filtration rate (GFR) 25.0±15.8 ml/min/1.73m2]. Sarcopenia was defined as reduced muscle function assessed by handgrip strength (<30th percentile of a population-based reference adjusted for sex and age) plus diminished muscle mass assessed by three different methods: A) midarm muscle circumference <90% of reference value; B) muscle wasting by subjective global assessment; and C) reduced skeletal muscle mass index (<10.76kg/m² men; <6.76kg/m² women) estimated by bioelectrical impedance analysis (BIA). Patients were followed for up to 40 months for all-cause mortality and there was no loss of follow-up. Results: The prevalence of sarcopenia was 9.8% (A), 9.4% (B) and 5.9% (C). The kappa agreement between the methods were 0.69 (A vs B), 0.49 (A vs C) and 0.46 (B vs C). During follow-up, 51 patients (18%) died, and the frequency of sarcopenia was significantly higher among non-survivors.In crude Cox analysis, sarcopenia diagnosed by the three methods was associated with a higher hazard for mortality; however, only sarcopenia diagnosed by method C remained as a predictor of mortality after multivariate adjustment. Conclusions: The prevalence of sarcopenia in CKD patients on conservative therapy varies according to the method applied. Sarcopenia defined as reduced handgrip strength and low skeletal muscle mass index estimated by BIA was an independent predictor of mortality in these patients.
- ItemSomente MetadadadosScreening for muscle wasting and dysfunction in patients with chronic kidney disease(Nature Publishing Group, 2016) Carrero, Juan J.; Johansen, Kirsten L.; Lindholm, Bengt; Stenvinkel, Peter; Cuppari, Lilian [UNIFESP]; Avesani, Carla M.Skeletal muscle mass and muscle function are negatively affected by a variety of conditions inherent to chronic kidney disease (CKD) and to dialysis treatment. Skeletal muscle mass and function serve as indicators of the nutritional and clinical state of CKD patients, and low values or derangements over time are strong predictors of poor patient outcomes. However, muscle size and function can be affected by different factors, may decline at different rates, and may have different patient implications. Therefore, operational definitions of frailty and sarcopenia have emerged to encompass these 2 dimensions of muscle health, i.e., size and functionality. The aim of this review is to appraise available methods for assessment of muscle mass and functionality, with an emphasis on their accuracy in the setting of CKD patients. We then discuss the selection of reference cutoffs for defining conditions of muscle wasting and dysfunction. Finally, we review definitions applied in studies addressing sarcopenia and frailty in CKD patients and discuss their applicability for diagnosis and monitoring.
- ItemSomente MetadadadosSíndrome da mobilidade comprometida: um novo conceito na funcionalidade do idoso(Universidade Federal de São Paulo (UNIFESP), 2014-09-24) Simamura, Mariane Aiko [UNIFESP]; Toniolo Neto, Joao Toniolo Neto [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Introduction. The approach of the musculoskeletal aging is now centered in the diagnosis and treatment of osteoporosis. The recognition of sarcopenia as a clinical entity is still restricted to a limited group of experts and their close relationship with osteoporosis, especially with regard to treatment, it is little discussed. Moreover, even under treatment for osteoporosis, elderly falls and fractures still present, indicating that only address the bone in isolation may not evolve prevents elderly with reduced mobility and free of adverse effects. Goals. General: 1. Propose a new form of assessment of the impairment of mobility of the elderly aiming at prevention and early intervention. Specific: 2. Review the new concepts of integration between bone and muscle. 3. Assess the importance of osteoporosis and sarcopenia creating new way of understanding between bone and muscle. Methodology: Essay based on literature review on the topic using the major databases; SciELO, LILACS, EMBASE, MEDLINE, Cocharane Library. Description of Mobility Committed Syndrome. Five items were chosen to compose the syndrome based on major risk factors involved in negative outcomes as mobility: osteoporosis, low appendicular lean mass, positive history of falls in the last year (at least one fall in the previous year), gait speed reduced and reduced handgrip strength.