Navegando por Palavras-chave "sistema venoso"

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    Disfunção endotelial venosa em pacientes com doença de Chagas sem insuficiência cardíaca
    (Sociedade Brasileira de Cardiologia - SBC, 2006-06-01) Plentz, Rodrigo Della Méa [UNIFESP]; Irigoyen, Maria Claudia [UNIFESP]; Muller, Andreia Simone [UNIFESP]; Casarini, Dulce Elena [UNIFESP]; Rubira, Marcelo Custodio; Moreno Junior, Heitor; Mady, Charles; Ianni, Bárbara Maria; Krieger, Eduardo Moacir; Consolim-Colombo, Fernanda; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP); Universidade Estadual de Campinas (UNICAMP); Universidade de Cruz Alta
    OBJECTIVE: To analyze the venous endothelial function in Chagas' disease patients without heart failure. METHODS: The Chagas' disease Group (G1) was composed by 14 women and 2 men aged 46 ± 2,7 and the Control Group (G0) by 7 women and 1 man matched by age, weight and height. Dorsal Hand Vein Compliance Technique was used to evaluate the venous endothelial function. Crescent doses of phenylephrine were infused to get a 70% pre-constriction of the vein; after that, acetylcholine and sodium nitroprusside were respectively administrated to analyze the endothelium-dependent and -independent venodilation. RESULTS: No significant systemic hemodynamic changes were observed in both groups during the experiment. The necessary phenylephrine dose to reach 70% pre-constriction of the vein was significantly higher in the G1 (1116 ± 668,2 ng/ml) compared to G0 (103 ± 28 ng/ml) p = 0,05. The endothelium-dependent venous dilation was significantly lower in G1 (65,5 ± 8%) compared to G0 (137 ± 20 %) p = 0,009. No difference was observed in the endothelium-independent venous dilatation between groups. CONCLUSION: Patients with Chagas' disease without heart failure presented venous endothelial dysfunction.