Navegando por Palavras-chave "targeted therapy"

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    Cancer stem cell genomics: the quest for early markers of malignant progression
    (Expert Reviews, 2009-09-01) Okamoto, Oswaldo Keith [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Biologically distinct populations of neoplastic stem cells have been identified in a variety of human cancers, in which they are associated with the initial steps of tumorigenesis. the intrinsic properties of self-renewal, clonogenicity and multipotency, along with a longer half-life within the body, may render normal adult stem cells more prone to accumulate genetic mutations leading to neoplastic transformation, as predicted by the cancer stem cell hypothesis. Tumor formation is also associated with the pluripotency of embryonic stem cells and may be induced as a consequence of complete dedifferentiation of mature cells, as recently reported for induced pluripotent stem cells. the tumor-initiating cell phenotype may result from genetic alterations affecting the expression of critical genes regulating typical stem cell processes such as self-renewal and pluripotency, in addition to genes determining stem cell senescence or longevity. Detailed genome-wide analysis of cancer stem cells and respective normal counterparts will help elucidate the cellular and molecular nature of tumors, providing fundamental information about the initial steps toward malignant transformation. Devising ways of detecting such genetic and epigenetic alterations and cell populations displaying them would allow medical interventions at the early phases of cancer development, thereby improving the chances of favorable clinical outcomes.
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    Guidelines for the management of neuroendocrine tumours by the Brazilian gastrointestinal tumour group
    (Cancer Intelligence Ltd, 2017) Riechelmann, Rachel P.; Weschenfelder, Rui F.; Costa, Frederico P.; Andrade, Aline Chaves; Osvaldt, Alessandro Bersch; Quidute, Ana Rosa P.; dos Santos, Allan; Hoff, Ana Amelia O.; Gumz, Brenda; Buchpiguel, Carlos; Vilhena Pereira, Bruno S.; Lourenco Junior, Delmar Muniz; da Rocha Filho, Duilio Reis; Fonseca, Eduardo Antunes; Riello Mello, Eduardo Linhares; Makdissi, Fabio Ferrari; Waechter, Fabio Luiz; Carnevale, Francisco Cesar; Coura-Filho, George B.; de Paulo, Gustavo Andrade; Girotto, Gustavo Colagiovanni; Bezerra Neto, Joao Evangelista; Glasberg, Joao; Casali-da-Rocha, Jose Claudio; Rego, Juliana Florinda M.; de Meirelles, Luciana Rodrigues; Hajjar, Ludhmila; Menezes, Marcos; Bronstein, Marcello D.; Sapienza, Marcelo Tatit; Barisson Villares Fragoso, Maria Candida; Albergaria Pereira, Maria Adelaide; Barros, Milton; Forones, Nora Manoukian [UNIFESP]; Galvao do Amaral, Paulo Cezar; Scortegagna de Medeiros, Raphael Salles [UNIFESP]; Araujo, Raphael L. C.; Franca Bezerra, Regis Otaviano; Peixoto, Renata D'Alpino; Aguiar, Samuel, Jr.; Ribeiro, Ulysses, Jr.; Pfiffer, Tulio; Hoff, Paulo M.; Coutinho, Anelisa K.
    Neuroendocrine tumours are a heterogeneous group of diseases with a significant variety of diagnostic tests and treatment modalities. Guidelines were developed by North American and European groups to recommend their best management. However, local particularities and relativisms found worldwide led us to create Brazilian guidelines. Our consensus considered the best feasible strategies in an environment involving more limited resources. We believe that our recommendations may be extended to other countries with similar economic standards.