Navegando por Palavras-chave "testosterone and estradiol"

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    Avaliação do tratamento crônico com resveratrol sobre níveis glicêmicos e parâmetros reprodutivos de ratos com diabetes tipo 1 induzida pela estreptozotocina na pré-puberdade
    (Universidade Federal de São Paulo (UNIFESP), 2014-12-18) Simas, Joana Nogueres [UNIFESP]; Valdeolivas, Sandra Maria Miraglia Valdeolivas [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Aims/hypothesis: In Diabetes Mellitus, the persistent hyperglycemia unleashes the progression of several complications including the overproduction of reactive oxygen species and reproductive alterations. Resveratrol (RES) is antioxidant and antiapoptotic. We assessed the trilogy: type-1 Diabetes (DM1), male reproduction and RES-treatment. Methods: Eighty-four prepubertal male rats were distributed into 7 groups: sham-control (SC); RES-treated (R);resveratrol-vehicle-treated (RV); diabetic (D); diabetic-insulin-treated (DI); diabetic-RES-treated (DR), diabetic-insulin and RES-treated (DIR). DM1 was induced by a single intraperitoneal streptozotocin (STZ) injection (65 mg/kg) on the 30th day postpartum (dpp). Animals of DR, DIR and R groups received 150mg/day of RES by gavage for 42 consecutive days (from the 33 dpp). DI and DIR rats received subcutaneous injections of insulin (1U/100g bw/day) from the 5th day after the DM1 induction. The blood-glucose-measurement (BGM) of rats was obtained at 5 different time-points: before the STZ-treatment, at 33, 45, 64 and 75 dpp when they were submitted to euthanasia for morphometric and biometric testicular analyses, spermatic evaluation and hormonal dosages. Results: In the D group, BGM was higher than in DR, DI and DIR. Besides, morphometric testicular measurements and testosterone and estradiol dosages were lower than in DR and DIR; LH-dosage was also lower than in DR. The preputial-separation age was delayed in diabetes-induced groups. The DR and DIR groups showed an improvement of the sperm mitochondrial activity, epididymal sperm counts and of the frequency of morphologically normal sperms. Conclusions/interpretation: RES improved glycemia, sperm quantitative and qualitative parameters and hormonal profile in DM1-induced Rats.