Navegando por Palavras-chave "toxina botulínica"
Agora exibindo 1 - 3 de 3
Resultados por página
Opções de Ordenação
- ItemSomente MetadadadosComparação do uso da toxina botulínica e propranolol em pacientes com tremor vocal essencial e distônico(Universidade Federal de São Paulo (UNIFESP), 2013-10-21) Cruz, Grazzia Guglielmino da [UNIFESP]; Biase, Noemi Grigoletto de Biase [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Background: The vocal tremor produces a lot of discomfort and commitment in sociability in these patients. The vocal tremors are classified, in any body part, in resting tremor and action tremor. Among the action tremor thatcommits the voice, the essential is the most common and it is related with the attitude. The rarer seems to be the dystonic vocal tremor that is related with especific tasks. Botulinum toxin and oral medications have been used to vocal tremor, but with no comparative clinical trials. Purpose: The aim of this study was to verify and to compare the treatment responses of intramuscular application of botulinum toxin and the oral use of propranolol in essential vocal tremor and dystonic vocal tremor. Method: Clinical trial. This research was performed with fifteen patients with vocal tremor selected in two groups: essential vocal tremor and dystonic vocal tremor. After both groups had been treated with botulinum toxin and propranolol in distinct periods and randomly, they underwent by self assessment, flexible nasolaryngoscopy evaluation and perceptual, hearing and acoustic voice evaluation. Statistical analysis was performed with 0,05 (5%) rate of significance. Results: There were statistically significant improvement in the perceptual and hearing measures of vocal instability of dystonic vocal tremor after botulinum toxin application comparing with propranolol and the pretreatment. The acoustic measure variability in fundamental frequency proved to be reliable with significant decrease in dystonic vocal tremor with botulinum toxin comparing with propranolol and the pretreatment also. The flexible nasolaryngoscopy evaluation proved to be applicable parameter post treatment with botulinum toxin in dystonic vocal tremor patients. Conclusions: Essential vocal tremor and dystonic vocal tremor differ in responses to treatments. Dystonic vocal tremor responds significantly to botulinum toxin application, but not to propranolol oral use. The essential tremor does not respond significantly to any treatment described before.
- ItemAcesso aberto (Open Access)Head tremor in patients with cervical dystonia: different outcome?(Academia Brasileira de Neurologia - ABNEURO, 2008-12-01) Godeiro-Junior, Clecio [UNIFESP]; Felício, André Carvalho [UNIFESP]; Aguiar, Patricia C. [UNIFESP]; Borges, Vanderci [UNIFESP]; Silva, Sonia M.a. [UNIFESP]; Ferraz, Henrique B. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)OBJECTIVE: The association of cervical dystonia (CD) with other movement disorders have been already described, but data on clinical outcome regarding these patients are scant. The aim of this paper was to investigate whether patients with CD and head tremor (HT) would have a different outcome regarding to botulinum toxin type-A (BTX-A) treatment response and clinical and demographic parameters. METHOD: We retrospectively evaluated 118 medical charts of patients with CD and divided them into two groups: with (HT+) and without (HT-) head tremor. We compared the following clinical and demographic parameters: age at onset, disease duration, progression of symptoms, etiology, familial history, presence of hand tremor. We also analyzed the response to BTX-A according to Tsui score in both groups. RESULTS: The occurrence of head tremor in our sample was of 38.2%. The occurrence of postural hand tremor in the patients from the HT+ group was higher than in the HT- one (p=0.015) and if we compare BTX-A response in each group, we observe that patients with HT present a better outcome in a setting of longer follow-up. In HT+ group, Tsui score pre treatment was 10 (6-12.5) and after follow-up was 8 (5.5-10.5); p<0.001. In HT- group there was no significant difference 9 (7-12) in pre treatment and after follow-up; p=0.07. CONCLUSION: According to our data it seems that head tremor may influence the clinical outcome or treatment response with BTX-A in patients with CD.
- ItemAcesso aberto (Open Access)Treatment of Non-neurogenic Overactive Bladder with OnabotulinumtoxinA: Systematic Review and Meta-analysis of Prospective, Randomized, Placebo-controlled Clinical Trials(Federacao Brasileira Soc Ginecologia & Obstetricia-Febrasgo, 2018) Arruda, Raquel Martins [UNIFESP]; Takano, Claudia Cristina [UNIFESP]; Girão, Manoel João Batista Castello [UNIFESP]; Haddad, Jorge Milhem; Aleixo, Gabriel Francisco; Castro, Rodrigo Aquino [UNIFESP]We performed a systematic review and meta-analysis of randomized placebo-controlled trials that studied non-neurogenic overactive bladder patients who were treated with 100 units of onabotulinumtoxinA or placebo. The primary purpose of our study was to evaluate the clinical effectiveness with regard to urinary urgency, urinary frequency, nocturia, and incontinence episodes. Our secondary purpose consisted of evaluating the adverse effects. Our initial search yielded 532 entries. Of these, seven studies met all the inclusion criteria (prospective, randomized, placebo-controlled studies, >= 3 points on the Jadad scale) and were selected for analysis. For all primary endpoints, the toxin was more effective than placebo (p < 0.0001