Navegando por Palavras-chave "transaminases"

Agora exibindo 1 - 1 de 1
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Maternal antiretrovirals and hepatic enzyme, Hematologic abnormalities among human immunodeficiency virus type 1-uninfected infants - the NISDI perinatal study
    (Lippincott Williams & Wilkins, 2007-11-01) Mussi-Pinhata, Marisa M.; Aparecida, Maria; Rego, Maria Aparecida C.; Freimanis, Laura; Kakehasi, Fabiana M.; Machado, Daisy Maria; Cardoso, Edmundo M.; Read, Jennifer S.; NISDI Perinatal Protocol Study Grp; WESTAT Corp; Universidade Federal de São Paulo (UNIFESP); Universidade Federal de Minas Gerais (UFMG); Na Sa Conceicao Hosp; NICHD
    Objectives: To assess hepatic enzyme (HE) and hematologic abnormalities among human immunodeficiency virus-1-uninfected infants according to maternal antiretroviral regimen during pregnancy.Study Design: in a prospective cohort, HE and hematologic values of human immunodeficiency virus-1-uninfected, term infants with hospital discharge (HD) within 6 days after birth were evaluated. Maternal antiretroviral regimens were categorized as: 1 or 2 nucleoside reverse transcription inhibitors (NRTIs), highly active antiretroviral therapy (HAART)/protease inhibitor (PI), or HAART/non-NRTI.Results: Among 503 infants, 63% and 24% had HE and hemoglobin abnormalities, respectively, at HD. Most or all HE and hemoglobin abnormalities (96-100%) were grade 1 or 2. At HD, infants with maternal HAART/PI or HAART/non-NRTI were more likely to have elevated HE [adjusted odds ratio (AOR): 1.9, 2.4, respectively] compared with infants whose mothers received 1 or 2 NRTIs. Infants with maternal HAART/PI were less likely to have abnormal hemoglobin values at HD (AOR, 0.5) when compared with those whose mothers received 1 or 2 NRTIs. Persistently abnormal hemoglobin and HE values decreased with time, such that <10% of infants had abnormalities at 6 months of age.Conclusions: Maternal receipt of HAART regimens was associated with an increased risk of HE abnormalities, and maternal HAART/PI was associated with a lower risk of abnormal hemoglobin values, at HD. Abnormalities of HE and hemoglobin were generally mild and transient.