Navegando por Palavras-chave "vaccines papillomavirus"

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    Efeito da vacina contra papilomavírus humano (tipos 6, 11, 16 e 18) no tratamento de crianças com papilomatose respiratória recorrente
    (Universidade Federal de São Paulo (UNIFESP), 2015-12-16) Hermann, Juliana Sato [UNIFESP]; Pignatari, Shirley Shizue Nagata Pignatari [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Purpose: To evaluate whether the tetravalent vaccine against human papilomavírus (HPV) (types 6, 11, 16 and 18), when administered in a group of patients with juvenile-onset recurrent respiratory papillomatosis (RRP), influences the clinical course of the disease. Method: Uncontrolled intervention study of patients with juvenile-onset RRP of the Clinic of Pediatric Otorhinolaryngology, Federal University of São Paulo, where nine patients aged between 9-17 years received three doses of prophylactic quadrivalent vaccine against HVP (Gardasil®) and were followed for one year. The staging of disease, the intervals between relapses, the intervals between surgeries and their number during the year prior to vaccination and the first year of follow-up after vaccination were compared. Results: Eight patients had disease due to HPV-6 and one per HPV-11. There was no statistically significant change between the previous and subsequent years of vaccination in relation to clinical score (p = 0,083), anatomical score (p = 0,257), interval between relapses (p = 0,062), interval between surgery (p = 0,357) and the number of surgeries (p = 0,180). All patients had relapsed following vaccination. Conclusion: Vaccination with Gardasil® did not affect the clinical course of patients with juvenile-onset RRP during the study period.