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- ItemSomente MetadadadosNo changes in anatomical and functional glaucoma evaluation after trabeculectomy(Springer, 2006-05-01) Tavares, I. M.; Melo, LAS; Prata, J. A.; Galhardo, R.; Paranhos, A.; Mello, PAA; Universidade Federal de São Paulo (UNIFESP); Fed Univ Triangulo MineiroTo assess the influence of glaucoma filtration surgery on anatomical and functional tests for glaucoma evaluation.Twenty-five eyes (25 patients) with primary open-angle glaucoma were evaluated, prospectively. Data were collected on vision acuity, intraocular pressure, standard automated perimetry, frequency doubling technology perimetry, scanning laser polarimetry (GDx) and confocal scanning laser ophthalmoscopy (HRT II) before and 3-6 months after surgery.Mean (+/- SD) pre- and postoperative visual acuities (logMAR) were 0.28 (+/- 0.18) and 0.30 (+/- 0.17), respectively (P=0.346). in a mean time of 4.5 (+/- 1.1) months after surgery, the mean preoperative intraocular pressure of 20.7 (+/- 5.4) mmHg decreased to 11.04 (+/- 2.52) mmHg (P < 0.001). the results of the standard automated perimetry, frequency doubling technology perimetry, scanning laser polarimetry and confocal scanning laser ophthalmoscopy diagnostic methods revealed no significant difference (P > 0.162) between pre and postoperative values and no significant correlation (P > 0.296) between intraocular pressure reduction and value changes.No significant change on any test variable was detected after glaucoma filtration surgery. Trabeculectomy does not appear to influence standard automated perimetry, frequency doubling technology perimetry, scanning laser polarimetry and confocal scanning laser ophthalmoscopy (HRT II) results after a 4.5-month period of surgery in early to moderate glaucoma.
- ItemSomente MetadadadosSight-dependent quality of life and ophthalmic findings in a group of Brazilian patients with multiple sclerosis(Assoc Arquivos Neuro- Psiquiatria, 2011-10-01) Fragoso, Yara Dadalti [UNIFESP]; Nosé, Ricardo Menon; Nosé, Regina Aidar Menon; Nosé, Walton [UNIFESP]; Vieira, Simone; Finkelsztejn, Alessandro; Univ Metropolitana SAntos UNIMES; MS Reference Ctr DRS IV; Eye Clin Day Hosp; Universidade Federal de São Paulo (UNIFESP); Univ Metropolitana Santos; Hosp Clin Porto AlegreObjective: To assess the visual quality of life in patients with multiple sclerosis (MS), and to observe whether this parameter could be correlated to the findings of the ophthalmologic examination. Method: The translated and validated 25-Item National Eye Institute Visual Function Questionnaire (VFQ-25) was used to assess the visual quality of life. Clinical data on MS, visual acuity, visual fields, optic coherence tomography (OCT) and disc cupping were used for assessing correlation with VFQ-25. Results: The mean VFQ-25 value was 78.6+/-18.2% in 27 patients. VFQ-25 did not correlate with patients' ages, with disability (EDSS), disease duration or medication use. Visual acuity showed a relatively poor (<60%) correlation to VFQ-25, while no correlation could be established between visual fields, OCT and disc cupping with VFQ-25. Conclusion: MS patients present several alterations in their eyes and sight that cannot be assessed by isolated measures. Ophthalmological examination of these patients must include many parameters not usually used in standard ophthalmologic consultations.
- ItemSomente MetadadadosVisual electrophysiologic findings in patients from an extensive Brazilian family with Leber's hereditary optic neuropathy - Visual electrophysiology in LHON(Kluwer Academic Publ, 2004-03-01) Salomão, Solange Rios [UNIFESP]; Berezovsky, Adriana [UNIFESP]; Andrade, R. E.; Belfort, R.; Carelli, Valerio; Sadun, Alfredo A.; Universidade Federal de São Paulo (UNIFESP); Univ Bologna; Univ So CalifLeber's hereditary optic neuropathy (LHON) is a maternally inherited disease, associated with mitochondrial DNA (mtDNA) point mutations and characterized by bilateral, usually sequential, rapid loss of central vision. the purpose of this study was to investigate electrophysiologically a small cohort of members from an extensive Brazilian family affected by LHON. Pattern-reversal visual evoked potentials (PVEP), and full-field electroretinograms (ERG) were performed on the four index members, all carrying the 11778 homoplasmic mtDNA mutation. They were a 14-year-old recently affected male, his unaffected mother, and her two affected brothers. the three affected members all had bilateral profound visual loss with visual acuities that ranged from 20/250 to CF, cecocentral defects, and severe dyschromatopsia (by FM-100). the unaffected (carrier) female had normal visual acuities, visual fields and color discrimination. Severely prolonged P100 latencies and decreased N75-P100 peak amplitudes were found in pattern-reversal VEPs for three affected members. Normal PVEP responses were found in the carrier female. Rod and cone ERG responses were normal in two affected members, but both the carrier mother and her affected son showed reduced peak-to-peak amplitude for single-flash cone response and 30 Hz flicker, with normal b-wave implicit times. Thus, optic nerve function, evaluated by PVEP, was severely reduced in LHON affected members and normal in the carrier female. However, reduced ERG cone responses suggest that LHON can also affect retinal elements, even in the absence of fundus and other clinical changes that constitute the full and classical expression of LHON.