Navegando por Palavras-chave "whole-cell (WC) modeling"

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    Toward Community Standards and Software for Whole-Cell Modeling
    (Ieee-Inst Electrical Electronics Engineers Inc, 2016) Waltemath, Dagmar; Karr, Jonathan R.; Bergmann, Frank T.; Chelliah, Vijayalakshmi; Hucka, Michael; Krantz, Marcus; Liebermeister, Wolfram; Mendes, Pedro; Myers, Chris J.; Pir, Pinar; Alaybeyoglu, Begum; Aranganathan, Naveen K.; Baghalian, Kambiz; Bittig, Arne T.; Burke, Paulo Eduardo Pinto [UNIFESP]; Cantarelli, Matteo; Chew, Yin Hoon; Costa, Rafael S.; Cursons, Joseph; Czauderna, Tobias; Goldberg, Arthur P.; Gomez, Harold F.; Hahn, Jens; Hameri, Tuure; Gardiol, Daniel F. Hernandez; Kazakiewicz, Denis; Kiselev, Ilya; Knight-Schrijver, Vincent; Knuepfer, Christian; Koenig, Matthias; Lee, Daewon; Lloret-Villas, Audald; Mandrik, Nikita; Medley, J. Kyle; Moreau, Bertrand; Naderi-Meshkin, Hojjat; Palaniappan, Sucheendra K.; Priego-Espinosa, Daniel; Scharm, Martin; Sharma, Mahesh; Smallbone, Kieran; Stanford, Natalie J.; Song, Je-Hoon; Theile, Tom; Tokic, Milenko; Tomar, Namrata; Toure, Vasundra; Uhlendorf, Jannis; Varusai, Thawfeek M.; Watanabe, Leandro H.; Wendland, Florian; Wolfien, Markus; Yurkovich, James T.; Zhu, Yan; Zardilis, Argyris; Zhukova, Anna; Schreiber, Falk
    Objective: Whole-cell (WC) modeling is a promising tool for biological research, bioengineering, and medicine. However, substantial work remains to create accurate comprehensive models of complex cells. Methods: We organized the 2015 Whole-Cell Modeling Summer School to teach WC modeling and evaluate the need for new WC modeling standards and software by recoding a recently published WC model in the Systems Biology Markup Language. Results: Our analysis revealed several challenges to representing WC models using the current standards. Conclusion: We, therefore, propose several new WC modeling standards, software, and databases. Significance: We anticipate that these new standards and software will enable more comprehensive models.