Navegando por Palavras-chave "zolpidem"

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    Acute neurophysiological effects of the hypnotic zolpidem in healthy volunteers
    (Elsevier B.V., 2005-05-01) Lucchesi, L. M.; Braga, NID; Manzano, G. M.; Pompeia, S.; Tufik, Sergio [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Introduction: the imidazopyridine zolpidem is a hypnotic drug with relative selectivity for the benzodiazepine (BZP) type 1 receptor subtypes displaying a different biochemical structure to that of BZPs. Little is known of its electrophysiological effects.Purpose: the aim of the present study was to investigate the acute neurophysiological effects of clinical oral doses of zolpidem.Methods: This was a double blind, independent group design study. Thirty-six young, healthy volunteers were randomly allocated to one of three groups-zolpidem (5 mg and 10 mg) and placebo. in addition to ERPs, behavioural measures were used to examine sedative effects of the drug.Results: ERPs were affected in a similar way to that described after sedative/hypnotic drug ingestion: increased N2 and P3 latencies and decreased N2 and P3 amplitudes. However, contrary to what is expected of a hypnotic drug, there was no change with N1 while P2 amplitude increased after the highest dose.Conclusions: Because zolpidem showed different effects in different components, it seems to first enhance or preserve initial orienting (no change in NI), after an increase of P2 and then drastically diminish resource allocation (affecting N2 and P3 latencies and amplitudes). the study with ERPs, therefore, allows a more direct moment to moment investigation of finer mechanisms of changes in cerebral processes underlying the acute ingestion of the drug in question. the effects on N2 and P3 amplitudes and latencies were similar to those of other sedative/hypnotic drugs. However, zolpidem led to an unexpected increase in P2 amplitude; this effect may be related to its selective receptor binding profile and warrants further research. (c) 2005 Elsevier Inc. All rights reserved.
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    Zolpidem and memory: a study using the process-dissociation procedure
    (Springer, 2004-07-01) Pompeia, S.; Lucchesi, L. M.; Bueno, OFA; Manzano, G. M.; Tufik, Sergio [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Rationale. There is a dearth of studies which have employed sophisticated paradigms to investigate the effects of zolpidem on memory. Objectives. To explore anterograde cognitive deficits induced by acute oral doses of zolpidem by means of the process-dissociation procedure (PDP). Methods. the present study followed a placebo-controlled, double-blind, parallel-group design. Young, healthy females were randomly allocated to one of three treatments with 12 subjects each: placebo, 5 mg and 10 mg zolpidem. Two word-stem completion tasks were carried out close to theoretical peak-plasma concentration: a) direct inclusion task with cued recall, in which participants had to try to use words seen at study to complete stems; and b) direct exclusion task, in which words seen at study were to be avoided as completions. the PDP was applied to the results in these tasks to yield indices of explicit/controlled (C) and implicit/automatic (A) memory. Classical psychometric tests were also carried out. Results. Zolpidem 10 mg led to cognitive effects similar to benzodiazepines (except for the atypical lorazepam), including impairment of exclusion, but not inclusion-task performance. Results of the application of the PDP were inconclusive but concurred with the pattern established in previously published work on benzodiazepine effects, i.e. that zolpidem (10 mg) impaired C. Conclusions. Zolpidem leads to cognitive effects similar to most benzodiazepines. Although the application of PDP in drug studies may be counterproductive in view of methodological difficulties that are discussed, the pattern of effects on the stem-completion tasks involved in this paradigm is potentially useful in the investigation of cognitive effects of psychoactive drugs.