Teses e Dissertações

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Navegando Teses e Dissertações por Palavras-chave "4-Nitroquinoline-1-Oxide"

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    Atividade Quimioprotetora Do Extrato De Cenoura Roxa (Daucus Carota) Na Carcinogênese Bucal Induzida Pelo 4-Nitroquinolina 1-Óxido Em Ratos
    (Universidade Federal de São Paulo (UNIFESP), 2018-05-09) Soares, Glaucia Resende [UNIFESP]; Ribeiro, Daniel Araki [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    The Aim Of This Study Was To Evaluate The Chemopreventive Potential Of Purple Carrot Extract Following Rat Tongue Carcinogenesis Induced By 4-Nitroquinoline 1-Oxide (4nqo). For This Purpose, Histopathological Analysis, Proliferative Status, Antioxidant Activity And Inflammatory Status Were Investigated In This Setting. A Total Of 20 Male Rats Were Distributed Into Four Groups As Follows (N = 5 Per Group): Group 1"Free Access To Water And Commercial Diet For 12 Weeks; Group 2"Received 4nqo At 50 Ppm Dose In Drinking Water Daily And Commercial Diet For 12 Weeks; Group 3"Free Access To Water And Received Diet Supplemented With Purple Carrot Extract (0.1 G/Kg) For 12 Weeks; And Group 4"Received 4nqo At 50 Ppm Dose In Drinking Water Daily And Diet Supplemented With Purple Carrot Extract (0.1 G/Kg) For 12 Weeks. Histopathological Analysis Revealed That Animals Treated With Purple Carrot Extract Reduced The Oral Lesions Such As Dysplasia And Squamous Cell Carcinoma. Animals With Oral Preneoplastic Lesions And Treate