Teses e Dissertações

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Navegando Teses e Dissertações por Palavras-chave "5-Ht2"

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    Participação da neurotransmissão serotoninérgica do colículo inferior na modulação da resposta de inibição por pré- pulso do reflexo de sobressalto acústico e interação social em ratos wistar
    (Universidade Federal de São Paulo (UNIFESP), 2017-03-23) Oliveira, Rodolpho Pereira de [UNIFESP]; Silva, Regina Cláudia Barbosa da [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Schizophrenia is a devastating psychiatric disorder that affects approximately 1% of the population over a lifetime, and generally affects individuals in the prime of their productive potential. The relationship between serotonergic dysfunction and schizophrenia began with the discovery of the effects of lysergic acid diethylamide (LSD) that shows high affinity for the 5-HT2A receptor, and that generated delusions and hallucinations which are positive symptoms of schizophrenia. Another substance, 2,5-dimethoxy-4-iodoanfetamine (DOI), also displays hallucinogenic properties and 5- HT2A antagonism as LSD. An animal model widely used, based on attentional processes, is the model of pre-pulse inhibition (PPI) of the startle reflex. The primary neuronal pathway, mediating PPI response is in the brainstem, and the inferior colliculus (IC) is a key structure in this circuitry. One of the main negative symptoms of schizophrenia is the social withdrawal that leads to important losses in the personal and professional sphere of the individual. In this sense, the objective of this study was to investigate the role of serotonergic neurotransmission of the IC in the modulation of PPI response and social interaction. To this end, we microinjected an agonist and an antagonist of 5-HT2A receptors, DOI (10.0 ug/0.3uL ), and ritanserin (4 ug/0.3uL ), respectively in the IC of these animals. In an attempt to establish a parallel with the clinic, we verified whether pre-treatment with clozapine (5 mg/kg) prior to intracollicular microinjection of DOI could reverse the deficits of PPI and social interaction. The results showed that the microinjection of DOI into de IC produced deficits in PPI and social interaction that were reversed by pretreatment with clozapine. The microinjection of ritanserin in this structure did not produce any effect on PPI and social interaction responses. Together, our results point to the involvement of the serotonergic system of the IC as a critical neural substrate in mediating these responses.