Effect of intraoperative intravenous lidocaine on pain and plasma interleukin-6 in patients undergoing hysterectomy

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dc.contributor.authorOliveira, Caio Marcio Barros de [UNIFESP]
dc.contributor.authorSakata, Rioko Kimiko [UNIFESP]
dc.contributor.authorSlullitel, Alexandre
dc.contributor.authorSalomão, Reinaldo [UNIFESP]
dc.contributor.authorLanchote, Vera Lucia
dc.contributor.authorIssy, Adriana Machado [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionHosp Sao Domingos
dc.contributor.institutionSoc Anestesiol Estado Maranhao
dc.contributor.institutionAssoc Paulista Med
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T14:40:05Z
dc.date.available2016-01-24T14:40:05Z
dc.date.issued2015-03-01
dc.description.abstractBackground and objectives: Interleukin-6 (IL-6) is a predictor of trauma severity. the purpose of this study was to evaluate the effect of intravenous lidocaine on pain severity and plasma IL-6 after hysterectomy.Method: A prospective, randomized, comparative, double-blind study with 40 patients, aged 18-60 years. G1 received lidocaine (2 mg.kg(-1).h(-1)) or G2 received 0.9% saline solution during the operation. Anesthesia was induced with O-2/isoflurane. Pain severity (T0: awake and 6, 12, 18 and 24 hours), first analgesic request, and dose of morphine in 24 hours were evaluated. IL-6 was measured before starting surgery (TO), five hours after the start (T5), and 24 hours after the end of surgery (124).Results: There was no difference in pain severity between groups. There was a decrease in pain severity between TO and other measurement times in G1. Time to first supplementation was greater in G2 (76.0 104.4 min) than in G1 (26.7 23.3 min). There was no difference in supplemental dose of morphine between G1 (23.5 12.6 mg) and G2 (18.7 +/- 11.3 mg). There were increased concentrations of IL-6 in both groups from TO to T5 and T24. There was no difference in IL-6 dosage between groups. Lidocaine concentration was 856.5 +/- 364.1 ng.mL(-1) in T5 and 30.1 +/- 14.2 ng.mL(-1) in T24.Conclusion: Intravenous lidocaine (2 mg.kg(-1).h(-1)) did not reduce pain severity and plasma levels of IL-6 in patients undergoing abdominal hysterectomy. (C) 2014 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Unifesp, São Paulo, SP, Brazil
dc.description.affiliationHosp Sao Domingos, Serv Dor, Sao Luis, MA, Brazil
dc.description.affiliationSoc Anestesiol Estado Maranhao, Sao Luis, MA, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Setor Dor, Dept Anestesiol Dor & Terapia Intensiva, Unifesp, São Paulo, SP, Brazil
dc.description.affiliationAssoc Paulista Med, Dept Anesthesiol, São Paulo, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Infectol, Unifesp, São Paulo, SP, Brazil
dc.description.affiliationUniv São Paulo, Fac Ciencias Farmaceut Ribeirao Preto, São Paulo, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Unifesp, São Paulo, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Setor Dor, Dept Anestesiol Dor & Terapia Intensiva, Unifesp, São Paulo, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Infectol, Unifesp, São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent92-98
dc.identifierhttp://dx.doi.org/10.1016/j.bjan.2013.07.017
dc.identifier.citationRevista Brasileira de Anestesiologia. New York: Elsevier B.V., v. 65, n. 2, p. 92-98, 2015.
dc.identifier.doi10.1016/j.bjan.2013.07.017
dc.identifier.fileS0034-70942015000200092-en.pdf
dc.identifier.fileS0034-70942015000200092-es.pdf
dc.identifier.fileS0034-70942015000200092-pt.pdf
dc.identifier.issn0034-7094
dc.identifier.scieloS0034-70942015000200092
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38779
dc.identifier.wosWOS:000352509700002
dc.language.isopor
dc.publisherElsevier B.V.
dc.relation.ispartofRevista Brasileira de Anestesiologia
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectLidocaineen
dc.subjectintravenouslyen
dc.subjectPostoperative painen
dc.subjectHysterectornyen
dc.subjectInterleukin-6en
dc.titleEffect of intraoperative intravenous lidocaine on pain and plasma interleukin-6 in patients undergoing hysterectomyen
dc.title.alternativeEfecto de la lidocaína venosa intraoperatoria sobre el dolor e interleucina-6 plasmática en pacientes sometidas a histerectomíaes
dc.title.alternativeEfeito da lidocaína venosa intraoperatória sobre dor e interleucina-6 plasmática em pacientes submetidas a histerectomiapt
dc.typeinfo:eu-repo/semantics/article
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