Impairment of male reproductive function after sleep deprivation

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dc.contributor.authorAlvarenga, Tathiana A. [UNIFESP]
dc.contributor.authorHirotsu, Camila [UNIFESP]
dc.contributor.authorMazaro-Costa, Renata
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorAndersen, Monica L. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.date.accessioned2016-01-24T14:40:27Z
dc.date.available2016-01-24T14:40:27Z
dc.date.issued2015-05-01
dc.description.abstractObjective: To evaluate the influence of sleep loss on sexual behavior, hormone levels, sperm parameters, and testis-specific gene expression in male rats.Design: Experimental research.Setting: Animal laboratory.Animal(s): Male adult Wistar-Hannover rats.Intervention(s): Sexually experienced rats were subjected to paradoxic sleep deprivation (PSD) for 96 hours or sleep restriction (SR) for 21 days or kept in their home cage as control (CTRL).Main Outcome Measure(s): Sexual behavior, hormone levels, sperm parameters and expression of stress and nitric oxide-related genes were evaluated.Result(s): PSD significantly decreased sexual behavior compared with the CTRL group, whereas SR had no effect. the PSD group had significantly lower testosterone levels than the CTRL group. Both PSD and SR groups had lower sperm viabilities than the CTRL group. the decrease in the number of live sperm compared with the CTRL group was larger in the PSD group than in the SR group. Regarding testicular gene expression, both PSD and SR led to an increase of iNOS and hydroxysteroid 11 beta-dehydrogenase 1 expressions compared with the CTRL group. These changes were more pronounced in the PSD group. A significant increase in endothelial nitric oxide synthase expression was observed in the PSD groups compared with the CTRL group. No changes were observed in dimethylarginine dimethylaminohydrolase 1 and casein kinase 2 beta-polypeptide expressions.Conclusion(s): Sleep loss can promote marked changes in the male reproductive system of rats, particularly affecting spermatic function in part by interfering in the testicular nitric oxide pathway. (C) 2015 by American Society for Reproductive Medicine.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUniv Fed Goias, Dept Pharmacol, Goias, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAssociacao Fundo de Apoio a Pesquisa (AFIP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipMEC-SeSU (PET) fellowship
dc.description.sponsorshipIDFAPESP: 2014/15259-2
dc.description.sponsorshipIDFAPESP: 11/12325-6
dc.description.sponsorshipIDFAPESP: 12/05396-7
dc.format.extent1355-+
dc.identifierhttp://dx.doi.org/10.1016/j.fertnstert.2015.02.002
dc.identifier.citationFertility and Sterility. New York: Elsevier B.V., v. 103, n. 5, p. 1355-+, 2015.
dc.identifier.doi10.1016/j.fertnstert.2015.02.002
dc.identifier.issn0015-0282
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/39046
dc.identifier.wosWOS:000353843700042
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofFertility and Sterility
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectSleep restrictionen
dc.subjectsexual behavioren
dc.subjecttestosteroneen
dc.subjectprogesteroneen
dc.subjectspermen
dc.subjectreproductionen
dc.subjectnitric oxideen
dc.subjectmale raten
dc.subjectiNOSen
dc.subjecteNOSen
dc.titleImpairment of male reproductive function after sleep deprivationen
dc.typeinfo:eu-repo/semantics/article
unifesp.campusEscola Paulista de Medicina (EPM)pt
unifesp.departamentoPsicobiologia
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