Adrenal steroids synthesis during acute infectious diseases in infants

Página do item simplificado
dc.contributor.authorLongui, C. A.
dc.contributor.authorZlochevsky, ERM
dc.contributor.authorBachega, Tania Aparecida Sartori Sanchez [UNIFESP]
dc.contributor.authorMonte, O.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-06-15T18:07:32Z
dc.date.available2018-06-15T18:07:32Z
dc.date.issued2002-11-01
dc.description.abstractAn increase in plasma 17OHP found in infants requiring differential diagnosis between septic shock and adrenal failure led us to look for adrenal steroids pattern during infection. Infants and Methods: 56 infants, 1-6 months old, were studied during infection of different degrees of severity. Plasma cortisol, 17OHP, androstenedione, DHEA, DHEA-S and testosterone were measured.Results: 24 patients showed an expected cortisol elevation. One child had a low cortisol level. The concentration of 17OHP was above 6.0 nmol/l (200 ng/dl) in 41 patients and above 30.2 nmol/l (1,000 ng/dl) in 10. Higher 17OHP levels and more severe diseases correlated positively.Conclusions: During infectious diseases some patients demonstrated not only cortisol elevation but also 17OHP as high as that observed in NC-CAH. We suggest that if 17OHP elevation is not characteristic of SL-CAH, glucocorticoid therapy should be started and an ACTH test should be performed after recovery before ruling out this pathology.en
dc.description.affiliationSanta Casa Sao Paulo, Sch Med, Pediat Endocrinol Unit, Dept Pediat, Sao Paulo, Brazil
dc.description.affiliationHosp Municipal Infantil Menino Jesus, Pediat Intens Care Unit, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Med, Dept Endocrinol, Endocrinol Unit Dev & Hormones, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Med, Dept Endocrinol, Mol Genet Lab, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1515-1523
dc.identifierhttp://dx.doi.org/10.1515/JPEM.2002.15.9.1515
dc.identifier.citationJournal Of Pediatric Endocrinology & Metabolism. London: Freund Publishing House Ltd, v. 15, n. 9, p. 1515-1523, 2002.
dc.identifier.doi10.1515/JPEM.2002.15.9.1515
dc.identifier.issn0334-018X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/44537
dc.identifier.wosWOS:000179823400008
dc.language.isoeng
dc.publisherFreund Publishing House Ltd
dc.relation.ispartofJournal Of Pediatric Endocrinology & Metabolism
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectadrenal glanden
dc.subjectadrenal steroidsen
dc.subjectcortisolen
dc.subject17-hydroxyprogesteroneen
dc.subjectacute infectious diseasesen
dc.subjectcritical care patientsen
dc.titleAdrenal steroids synthesis during acute infectious diseases in infantsen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos