Maternal antiretrovirals and hepatic enzyme, Hematologic abnormalities among human immunodeficiency virus type 1-uninfected infants - the NISDI perinatal study

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dc.contributor.authorMussi-Pinhata, Marisa M.
dc.contributor.authorAparecida, Maria
dc.contributor.authorRego, Maria Aparecida C.
dc.contributor.authorFreimanis, Laura
dc.contributor.authorKakehasi, Fabiana M.
dc.contributor.authorMachado, Daisy Maria
dc.contributor.authorCardoso, Edmundo M.
dc.contributor.authorRead, Jennifer S.
dc.contributor.authorNISDI Perinatal Protocol Study Grp
dc.contributor.institutionWESTAT Corp
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionNa Sa Conceicao Hosp
dc.contributor.institutionNICHD
dc.date.accessioned2016-01-24T13:49:12Z
dc.date.available2016-01-24T13:49:12Z
dc.date.issued2007-11-01
dc.description.abstractObjectives: To assess hepatic enzyme (HE) and hematologic abnormalities among human immunodeficiency virus-1-uninfected infants according to maternal antiretroviral regimen during pregnancy.Study Design: in a prospective cohort, HE and hematologic values of human immunodeficiency virus-1-uninfected, term infants with hospital discharge (HD) within 6 days after birth were evaluated. Maternal antiretroviral regimens were categorized as: 1 or 2 nucleoside reverse transcription inhibitors (NRTIs), highly active antiretroviral therapy (HAART)/protease inhibitor (PI), or HAART/non-NRTI.Results: Among 503 infants, 63% and 24% had HE and hemoglobin abnormalities, respectively, at HD. Most or all HE and hemoglobin abnormalities (96-100%) were grade 1 or 2. At HD, infants with maternal HAART/PI or HAART/non-NRTI were more likely to have elevated HE [adjusted odds ratio (AOR): 1.9, 2.4, respectively] compared with infants whose mothers received 1 or 2 NRTIs. Infants with maternal HAART/PI were less likely to have abnormal hemoglobin values at HD (AOR, 0.5) when compared with those whose mothers received 1 or 2 NRTIs. Persistently abnormal hemoglobin and HE values decreased with time, such that <10% of infants had abnormalities at 6 months of age.Conclusions: Maternal receipt of HAART regimens was associated with an increased risk of HE abnormalities, and maternal HAART/PI was associated with a lower risk of abnormal hemoglobin values, at HD. Abnormalities of HE and hemoglobin were generally mild and transient.en
dc.description.affiliationWESTAT Corp, Rockville, MD 20850 USA
dc.description.affiliationUniv São Paulo, Dept Pediat, São Paulo, Brazil
dc.description.affiliationUniv Fed Minas Gerais, Dept Pediat, Belo Horizonte, MG, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pediat, São Paulo, Brazil
dc.description.affiliationNa Sa Conceicao Hosp, Porto Alegre, RS, Brazil
dc.description.affiliationNICHD, NIH, Dept Pediat Adolescent & Mat, AIDS Branch, Bethesda, MD USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pediat, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1032-1037
dc.identifierhttp://dx.doi.org/10.1097/INF.0b013e31812f56ed
dc.identifier.citationPediatric Infectious Disease Journal. Philadelphia: Lippincott Williams & Wilkins, v. 26, n. 11, p. 1032-1037, 2007.
dc.identifier.doi10.1097/INF.0b013e31812f56ed
dc.identifier.issn0891-3668
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30140
dc.identifier.wosWOS:000250818300010
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofPediatric Infectious Disease Journal
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectinfanten
dc.subjectpregnancyen
dc.subjecttransaminasesen
dc.subjecthematopoiesisen
dc.subjectantiretroviralsen
dc.subjectLatin Americaen
dc.subjectCaribbeanen
dc.titleMaternal antiretrovirals and hepatic enzyme, Hematologic abnormalities among human immunodeficiency virus type 1-uninfected infants - the NISDI perinatal studyen
dc.typeinfo:eu-repo/semantics/article
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