Sporadic Inclusion Body Myositis: MRI Findings and Correlation With Clinical and Functional Parameters

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dc.citation.issue6
dc.citation.volume209
dc.contributor.authorGuimaraes, Julio Brandao [UNIFESP]
dc.contributor.authorZanoteli, Edmar
dc.contributor.authorLink, Thomas M.
dc.contributor.authorde Camargo, Leonardo V.
dc.contributor.authorFacchetti, Luca
dc.contributor.authorArtur, Lorenzo Nardo
dc.contributor.authorCorrea Fernandes, Artur da Rocha [UNIFESP]
dc.coverageReston
dc.date.accessioned2020-09-01T13:21:12Z
dc.date.available2020-09-01T13:21:12Z
dc.date.issued2017
dc.description.abstractOBJECTIVE. The purpose of this prospective study is to assess MRI findings in patients with sporadic inclusion body myositis (IBM) and correlate them with clinical and functional parameters. SUBJECTS AND METHODS. This study included 12 patients with biopsy-proven sporadic IBM. All patients underwent MRI of the bilateral upper and lower extremities. The images were scored for muscle atrophy, fatty infiltration, and edema pattern. Clinical data included onset and duration of disease. Muscle strength was measured using the Medical Research Council (MRC) scale, and functional status was assessed using the Modified Rankin Scale. Correlation between MRI and different clinical and functional parameters was calculated using the Spearman rank test and Pearson correlation. RESULTS. All patients showed MRI abnormalities, which were more severe within the lower limbs and the distal segments. The most prevalent MRI finding was fat infiltration. There was a statistically significant correlation between disease duration and number of muscles infiltrated by fat (r = 0.65; p = 0.04). The number of muscles with fat infiltration correlated with the sum of the scores of MRC (r = -0.60; p = 0.04) and with the Modified Rankin Scale (r = 0.48; p = 0.03). CONCLUSION. Our findings suggest that most patients with biopsy-proven sporadic IBM present with a typical pattern of muscle involvement at MRI, more extensively in the lower extremities. Moreover, MRI findings strongly correlated with clinical and functional parameters, because both the extent and severity of muscle involvement assessed by MRI and clinical and functional parameters are associated with the early onset of the disease and its duration.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Radiol, Sao Paulo, Brazil
dc.description.affiliationUniv Calif San Francisco, Dept Radiol & Biomed Imaging, 185 Berry St,Ste 350, San Francisco, CA 94158 USA
dc.description.affiliationDASA Lab, Dept Radiol, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Med Sch, Dept Neurol, Sao Paulo, Brazil
dc.description.affiliationUniv Brescia, Dept Radiol, Brescia, Italy
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Radiol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1340-1347
dc.identifierhttp://dx.doi.org/10.2214/AJR.17.17849
dc.identifier.citationAmerican Journal Of Roentgenology. Reston, v. 209, n. 6, p. 1340-1347, 2017.
dc.identifier.doi10.2214/AJR.17.17849
dc.identifier.issn0361-803X
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58121
dc.identifier.wosWOS:000415982900038
dc.language.isoeng
dc.publisherAmer Roentgen Ray Soc
dc.relation.ispartofAmerican Journal Of Roentgenology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectatrophyen
dc.subjectfat infiltrationen
dc.subjectidiopathic myopathyen
dc.subjectinflammatory myopathiesen
dc.subjectMRIen
dc.subjectsporadic body inclusion myositisen
dc.titleSporadic Inclusion Body Myositis: MRI Findings and Correlation With Clinical and Functional Parametersen
dc.typeinfo:eu-repo/semantics/article
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