Contribution of Molecular Allergen Analysis in Diagnosis of Milk Allergy

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dc.citation.issue7]
dc.citation.volume17]
dc.contributor.authorBartuzi, Zbigniew
dc.contributor.authorCocco, Renata Rodrigues [UNIFESP]
dc.contributor.authorMuraro, Antonella
dc.contributor.authorNowak-Wegrzyn, Anna
dc.coveragePhiladelphia
dc.date.accessioned2020-06-26T16:30:32Z
dc.date.available2020-06-26T16:30:32Z
dc.date.issued2017
dc.description.abstractPurpose of Review We sought to describe the available evidence supporting the utilization of the molecular allergen analysis (MAA) for diagnosis and management of cow milk protein allergy (CMPA). Recent Findings Cow milk proteins are among the most common food allergens in IgE- and non-IgE-mediated food allergic disorders in children. Most individuals with CMPA are sensitized to both caseins and whey proteins. Caseins are more resistant to high temperatures compared to whey proteins. Summary MAA is not superior to the conventional diagnostic tests based on the whole allergen extracts for diagnosis of CMPA. However, MAA can be useful in diagnosing tolerance to extensively heated milk proteins in baked foods. Children with CMPA and high levels of casein IgE are less likely to tolerate baked milk compared to children with low levels of casein IgE. Specific IgE-binding patterns to casein and betalactoglobulin peptides may predict the natural course of CMPA and differentiate subjects who are more likely to develop CMPA at a younger age versus those with a more persistent CMPA. Specific IgE-binding patterns to casein and beta-lactoglobulin peptides may also predict response to milk OIT and identify patients most likely to benefit from OIT.en
dc.description.affiliationNicolaus Copernicus Univ, Ludwik Rydygier Coll Med Bydgoszcz, Torun, Poland
dc.description.affiliationUniv Fed Sao Paulo, Dept Pediat, Allergy & Immunol Div, Sao Paulo, Brazil
dc.description.affiliationPadua Gen Univ Hosp, Dept Women & Child Hlth, Food Allergy Referral Ctr Veneto Reg, Padua, Italy
dc.description.affiliationJaffe Food Allergy Inst, Div Allergy & Immunol, One Gustave L Levy Pl,Box 1198, New York, NY 10029 USA
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Pediat, Allergy & Immunol Div, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1007/s11882-017-0716-z]
dc.identifier.citationCurrent Allergy And Asthma Reports. Philadelphia, v. 17, n. 7, p. -, 2017.
dc.identifier.doi10.1007/s11882-017-0716-z
dc.identifier.issn1529-7322
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53606
dc.identifier.wosWOS:000404138300003
dc.language.isoeng
dc.publisherCurrent Medicine Group
dc.relation.ispartofCurrent Allergy And Asthma Reports
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectBaked milk dieten
dc.subjectCaseinen
dc.subjectCow milk allergyen
dc.subjectMilk allergyen
dc.subjectMolecular allergen analysisen
dc.subjectMolecular diagnosisen
dc.subjectWhey proteinsen
dc.titleContribution of Molecular Allergen Analysis in Diagnosis of Milk Allergyen
dc.typeinfo:eu-repo/semantics/article
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