Challenges in the Therapy of Chromoblastomycosis

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dc.contributor.authorQueiroz-Telles, Flavio
dc.contributor.authorSantos, Daniel Wagner de C. L. [UNIFESP]
dc.contributor.institutionUniv Fed Parana
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionInst Infect Dis Emilio Ribas
dc.date.accessioned2016-01-24T14:31:50Z
dc.date.available2016-01-24T14:31:50Z
dc.date.issued2013-06-01
dc.description.abstractChromoblastomycosis (CBM) is an implantation mycosis mainly occurring in tropical and subtropical zones worldwide. If not diagnosed at early stages, patients with CBM require long-term therapy with systemic antifungals flanked by various physical treatment regimens. As in other neglected endemic mycoses, comparative clinical trials have not been performed for this disease; nowadays, therapy is mainly based on a few open trials and on expert opinions. Itraconazole, either as monotherapy or associated with other drugs, or with physical methods, is widely used. Recently, photodynamic therapy has been employed successfully in combination with antifungals in patients presenting with CBM. in the present paper, the most used therapeutic options against CBM are reviewed as well as the several factors that may have impact on the patient's outcome.en
dc.description.affiliationUniv Fed Parana, Dept Publ Hlth, BR-80600900 Curitiba, Parana, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Med, Special Mycol Lab, LEMI, São Paulo, Brazil
dc.description.affiliationInst Infect Dis Emilio Ribas, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Med, Special Mycol Lab, LEMI, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent477-488
dc.identifierhttp://dx.doi.org/10.1007/s11046-013-9648-x
dc.identifier.citationMycopathologia. Dordrecht: Springer, v. 175, n. 5-6, p. 477-488, 2013.
dc.identifier.doi10.1007/s11046-013-9648-x
dc.identifier.issn0301-486X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36384
dc.identifier.wosWOS:000319768900013
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofMycopathologia
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectImplantation mycosesen
dc.subjectSubcutaneous mycosesen
dc.subjectChromomycosisen
dc.subjectBlack fungien
dc.subjectMelanized fungien
dc.subjectDematiaceousen
dc.subjectFonsecaea sp.en
dc.subjectCladophialophora sp.en
dc.subjectVerrucousen
dc.subjectMuriformen
dc.subjectScleroticen
dc.subjectAntifungalsen
dc.subjectItraconazoleen
dc.subjectPosaconazoleen
dc.subjectTerbinafineen
dc.subjectPhotodynamic therapyen
dc.titleChallenges in the Therapy of Chromoblastomycosisen
dc.typeinfo:eu-repo/semantics/article
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