Morphological variations of hippocampal formation in epilepsy: Image, clinical and electrophysiological data

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dc.contributor.authorAndrade Hamad, Ana Paula [UNIFESP]
dc.contributor.authorCarrete, Henrique [UNIFESP]
dc.contributor.authorBianchin, Marino Muxfeldt
dc.contributor.authorFerrari-Marinho, Taissa [UNIFESP]
dc.contributor.authorLin, Katia [UNIFESP]
dc.contributor.authorTargas Yacubian, Elza Marcia [UNIFESP]
dc.contributor.authorPereira Vilanova, Luiz Celso [UNIFESP]
dc.contributor.authorGarzon, Eliana [UNIFESP]
dc.contributor.authorCaboclo, Luis Otavio [UNIFESP]
dc.contributor.authorSakamoto, Americo Ceiki [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T14:31:04Z
dc.date.available2016-01-24T14:31:04Z
dc.date.issued2013-01-01
dc.description.abstractMorphological variations of hippocampal formation (MVHF) are observed in patients with epilepsy but also in asymptomatic individuals. the precise role of these findings in epilepsy is not yet fully understood. This study analyzes the hippocampal formation (HF) morphology of asymptomatic individuals (n = 30) and of patients with mesial temporal lobe epilepsy associated with hippocampal sclerosis (MTLE-HS) (n = 68), patients with malformations of cortical development (MCD) (n = 34), or patients with pure morphological variations of hippocampal formation (pure MVHF) (n = 12). Main clinical and electrophysiological data of patients with MVHF were also analyzed. Morphological variations of hippocampal formation are more frequently observed in patients with MCD than in patients with MTLE-HS or in asymptomatic individuals. Patients with pure morphological variations of hippocampal formation showed higher incidence of extratemporal seizure onset. Refractoriness seems to be more associated with other abnormalities, like HS or MCD, than with the HF variation itself. Thus, although morphological HF abnormalities might play a role in epileptogenicity, they seem to contribute less to refractoriness. (C) 2012 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Hosp São Paulo, Dept Neurol & Neurocirurgia, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Diagnost Imagem, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Med Ribeirao Preto, Dept Neurociencias & Ciencias Comportamento, Ribeirao Preto, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Hosp São Paulo, Dept Neurol & Neurocirurgia, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Diagnost Imagem, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent67-70
dc.identifierhttp://dx.doi.org/10.1016/j.yebeh.2012.10.028
dc.identifier.citationEpilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 26, n. 1, p. 67-70, 2013.
dc.identifier.doi10.1016/j.yebeh.2012.10.028
dc.identifier.issn1525-5050
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35818
dc.identifier.wosWOS:000313511100013
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofEpilepsy & Behavior
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectHippocampal formationen
dc.subjectHippocampal sclerosisen
dc.subjectMalformation of cortical developmenten
dc.subjectMagnetic resonance imagingen
dc.subjectMorphological variationsen
dc.subjectEpilepsyen
dc.titleMorphological variations of hippocampal formation in epilepsy: Image, clinical and electrophysiological dataen
dc.typeinfo:eu-repo/semantics/article
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