Synthesis and Characterization of Methylene Blue-Containing Silica-Coated Magnetic Nanoparticles for Photodynamic Therapy

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dc.citation.issue1
dc.citation.volume17
dc.contributor.authorFudimura, Karina Amancio [UNIFESP]
dc.contributor.authorSeabra, Amedea Barozzi [UNIFESP]
dc.contributor.authorSantos, Marconi da Cruz [UNIFESP]
dc.contributor.authorHaddad, Paula Silvia [UNIFESP]
dc.coverageValencia
dc.date.accessioned2020-07-31T12:46:46Z
dc.date.available2020-07-31T12:46:46Z
dc.date.issued2017
dc.description.abstractSuperparamagnetic iron oxide nanoparticles (SPIONs), with appropriate surface coating, are commonly used for biomedical applications such as photodynamic therapy (PDT). This work describes the preparation and characterization of methylene blue (MB)-containing silica-coated SPIONs. Upon exposure to light, MB reacts with molecular oxygen and generates singlet oxygen (O-1(2)) which is cytotoxic and causes irreversible damage to tumor tissues. In this work, SPIONs were synthesized by co-precipitation and coated with a single/double silica layer. The photoactive molecule MB was entrapped in the silica layer deposited on the surface of SPIONs, leading to the formation of hybrid nanomaterials composed of a magnetic core and silica layer. The nanocomposite exhibited magnetic behavior at room temperature due to the presence of its Fe3O4 core. Structural and morphological characterizations were performed by X-ray diffraction (XRD), Fourier transformed infrared (FTIR), SQUID magnetic measurements, ultraviolet-visible spectroscopy, scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), and dynamic light scattering. The results showed the presence of a crystalline Fe3O4 magnetic core and amorphous silica phases. Kinetic measurements revealed O-1(2) generation by the nanoparticles upon irradiation with visible light (lambda = 532 nm or lambda = 633 nm). The results highlight the potential uses of SPIONs coated with MB-entrapped silica for PDT, whereby a sustained and localized generation of O-1(2) was successfully achieved.en
dc.description.affiliationUniv Fed Sao Paulo, Exact & Earth Sci Dept, BR-09913030 Diadema, SP, Brazil
dc.description.affiliationUnifespExact and Earth Sciences Department, Universidade Federal de São Paulo, CEP 09913030, Diadema, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipBrazilian Network on Nanotoxicology (MCTI/CNPq)
dc.description.sponsorshipLaboratory of Nanostructure Synthesis and Biosystem Interactions-NANOBIOSS (MCTI)
dc.description.sponsorshipIDFAPESP : 2014/13913-7
dc.description.sponsorshipIDFAPESP : 2012/17053-7
dc.format.extent133-142
dc.identifierhttp://dx.doi.org/10.1166/jnn.2017.12715
dc.identifier.citationJournal Of Nanoscience And Nanotechnology. Valencia, v. 17, n. 1, p. 133-142, 2017.
dc.identifier.doi10.1166/jnn.2017.12715
dc.identifier.issn1533-4880
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56356
dc.identifier.wosWOS:000397106600008
dc.language.isoeng
dc.publisherAmer Scientific Publishers
dc.relation.ispartofJournal Of Nanoscience And Nanotechnology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectIron Oxide Nanoparticlesen
dc.subjectNanomedicineen
dc.subjectMethylene Blueen
dc.subjectPhotodynamic Therapyen
dc.subjectSilicaen
dc.subjectSinglet Oxygenen
dc.titleSynthesis and Characterization of Methylene Blue-Containing Silica-Coated Magnetic Nanoparticles for Photodynamic Therapyen
dc.typeinfo:eu-repo/semantics/article
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