A randomized study of low-dose conjugated estrogens on sexual function and quality of life in postmenopausal women

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dc.contributor.authorGast, Michael J.
dc.contributor.authorFreedman, Murray A.
dc.contributor.authorVieweg, Alberta J.
dc.contributor.authorDe Melo, Nilson R.
dc.contributor.authorGirao, Manoel J. B. C. [UNIFESP]
dc.contributor.authorZinaman, Michael J.
dc.contributor.authorDyspareunia Study Grp
dc.contributor.institutionWyeth Pharmaceut
dc.contributor.institutionMed Coll Georgia
dc.contributor.institutionInst Saude & Ben Estar da Mulher
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionLoyola Univ Chicago
dc.date.accessioned2016-01-24T13:52:20Z
dc.date.available2016-01-24T13:52:20Z
dc.date.issued2009-03-01
dc.description.abstractObjective: To evaluate the effects of combined vaginal and oral low-dose estrogen plus progestogen therapy (EPT) on the frequency and severity of dyspareunia, sexual function, and quality of life in recently postmenopausal women.Methods: This outpatient, double-blind, randomized, placebo-controlled trial enrolled 285 healthy, sexually active postmenopausal women aged 45 to 65 years. Women received either one daily oral low-dose conjugated estrogens (0.45 mg)/medroxyprogesterone (1.5 mg) tablet for six 28-day cycles along with I g conjugated estrogens vaginal cream (0.625 mg), intravaginally for the first 6 weeks of the trial or a placebo cream and placebo tablet. Efficacy was evaluated using the McCoy Female Sexuality Questionnaire, self-reported daily diary cards, the Brief Index of Sexual Functioning-Women (BISF-W), and the Women's Health Questionnaire.Results: the EPT group had a significant decrease in the frequency of dyspareunia compared with baseline and placebo in an analysis of responses to the McCoy Female Sexuality Questionnaire. Also, EPT was associated with a significant improvement in a woman's level of sexual interest, frequency of orgasm, and pleasure of orgasm. There was no effect of EPT use on coital frequency. the EPT group had significant improvement in receptivity/initiation and relationship satisfaction, although not in other BISF-W domains, versus placebo (BISF-W analysis) and significant improvement versus placebo on most Women's Health Questionnaire responses.Conclusions: EPT provided a statistically significant improvement compared with placebo in dyspareunia, sexual experience, and quality of life as measured in this study. in general, EPT also improved self-reported sexual perception and enjoyment significantly compared with placebo.en
dc.description.affiliationWyeth Pharmaceut, Collegeville, PA USA
dc.description.affiliationMed Coll Georgia, Dept Obstet & Gynecol, Augusta, GA 30912 USA
dc.description.affiliationInst Saude & Ben Estar da Mulher, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Gynaecol, São Paulo, Brazil
dc.description.affiliationLoyola Univ Chicago, Dept Obstet & Gynaecol, Maywood, IL USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Gynaecol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipWyeth, Collegeville, PA
dc.description.sponsorshipPREMARIN
dc.format.extent247-256
dc.identifierhttp://dx.doi.org/10.1097/gme.0b013e318184c440
dc.identifier.citationMenopause-the Journal of the North American Menopause Society. Philadelphia: Lippincott Williams & Wilkins, v. 16, n. 2, p. 247-256, 2009.
dc.identifier.doi10.1097/gme.0b013e318184c440
dc.identifier.issn1072-3714
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31368
dc.identifier.wosWOS:000264064100007
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofMenopause-the Journal of the North American Menopause Society
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectHormone therapyen
dc.subjectConjugated estrogensen
dc.subjectSexual functionen
dc.subjectQuality of lifeen
dc.subjectDyspareuniaen
dc.subjectPremarinen
dc.titleA randomized study of low-dose conjugated estrogens on sexual function and quality of life in postmenopausal womenen
dc.typeinfo:eu-repo/semantics/article
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