Vasoactive properties of synthetic blood substitutes

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dc.contributor.authorFigueiredo, Luis Francisco Poli de [UNIFESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-18T11:04:00Z
dc.date.available2018-06-18T11:04:00Z
dc.date.issued1998-01-01
dc.description.abstractThere is a great need for the development of a safe and efficient blood substitute, to overcome the important limitations of homologous blood transfusion. Currently available cell-free hemoglobin-based oxygen-carrying solutions present oxygen transport and exchange properties similar to blood and potential benefits over conventional transfusion, including large supply, absence of transfusion reactions, no need for cross-matching, no risk for transmission of disease and long shelf life. Several experimental studies have suggested that cell-free hemoglobin is a vasoactive agent. In animal models of hemorrhagic shock, small doses of cell-free modified hemoglobin restore arterial pressure, promote adequate tissue oxygenation, and improve survival, when compared with fluids with no oxygen-carrying capacity. On the other hand, it has been demonstrated that hemoglobin-induced vasoconstriction may result in decreased cardiac output, reduced blood flow to vital organs and severe pulmonary hypertension. Cell-free hemoglobin solutions cause their presser effects by binding and scavenging nitric oxide. Although hemoglobin within the red blood cells is the natural scavenger of NO, when the hemoglobin is free in solution, NO is inactivated to a greater extend. Cell-free hemoglobins are on advanced clinical trials, despite the fact that several concerns raised by experimental studies have not been adequately addressed in early clinical trials. The development of a safe and efficient blood substitute depends on the availability of these products for critical evaluation by the scientific community before the widespread clinical use of these blood substitutes.en
dc.description.affiliationUniv Sao Paulo, Inst Coracao, Fac Med, Dept Cardiopneumonol, BR-05403000 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent403-410
dc.identifierhttp://www.medicinabuenosaires.com/demo/revistas/vol58-98/4/syntheticblood.htm
dc.identifier.citationMedicina-buenos Aires. Buenos Aires: Medicina (buenos Aires), v. 58, n. 4, p. 403-410, 1998.
dc.identifier.issn0025-7680
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/44885
dc.identifier.wosWOS:000075991300011
dc.language.isoeng
dc.publisherMedicina (buenos Aires)
dc.relation.ispartofMedicina-buenos Aires
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectblood substitutesen
dc.subjecthemoglobinen
dc.subjectshocken
dc.subjectnitric oxideen
dc.subjectvasoconstrictionen
dc.titleVasoactive properties of synthetic blood substitutesen
dc.typeinfo:eu-repo/semantics/article
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