Mesenchymal stromal cells modulate gut inflammation in experimental colitis

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dc.citation.issue1
dc.citation.volume26
dc.contributor.authorde Aguiar, Cristhiane Favero
dc.contributor.authorCastoldi, Angela
dc.contributor.authorAndrade-Oliveira, Vinicius
dc.contributor.authorIgnacio, Aline
dc.contributor.authorda Cunha, Flavia Franco [UNIFESP]
dc.contributor.authorFerreira Felizardo, Raphael Jose [UNIFESP]
dc.contributor.authorBassi, Enio Jose
dc.contributor.authorSaraiva Camara, Niels Olsen [UNIFESP]
dc.contributor.authorde Almeida, Danilo Candido [UNIFESP]
dc.coverageBasel
dc.date.accessioned2020-07-08T13:09:49Z
dc.date.available2020-07-08T13:09:49Z
dc.date.issued2018
dc.description.abstractInflammatory bowel diseases (IBDs) affect millions of people worldwide and their frequencies in developed countries have increased since the twentieth century. In this context, there is an intensive search for therapies that modulate inflammation and provide tissue regeneration in IBDs. Recently, the immunomodulatory activity of adipose tissue-derived mesenchymal stromal cells (ADMSCs) has been demonstrated to play an important role on several immune cells in different conditions of inflammatory and autoimmune diseases. In this study, we explored the immunomodulatory potential of ADMSC in a classical model of DSS-induced colitis. First, we found that treatment of mice with ADMSC ameliorated the severity of DSS-induced colitis, reducing colitis pathological score and preventing colon shortening. Moreover, a prominent reduction of pro-inflammatory cytokines levels (i.e., IFN-gamma, TNF-alpha, IL-6 and MCP-1) was observed in the colon of animals treated with ADMSC. We also observed a significant reduction in the frequencies of macrophages (F4/80(+)CD11b(+)) and dendritic cells (CD11c(+)CD103(+)) in the intestinal lamina propria of ADMSC-treated mice. Finally, we detected the up-regulation of immunoregulatory-associated molecules in intestine of mice treated with ADMSCs (i.e., elevated arginase-1 and IL-10). Thus, this present study demonstrated that ADMSC modulates the overall gut inflammation (cell activation and recruitment) in experimental colitis, providing support to the further development of new strategies in the treatment of intestinal diseases.en
dc.description.affiliationUniv Sao Paulo, Inst Biomed Sci 4, Dept Immunol, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Nephrol Div, Dept Med, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Alagoas, Inst Biol Sci & Hlth, Alagoas, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Med, LIM 16, Sao Paulo, Brazil
dc.description.affiliationAv Prof Lineu Prestes 1730 Lab 238 Cidade Univ, BR-05508000 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Nephrol Div, Dept Med, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFAPESP
dc.description.sponsorshipCAPES
dc.description.sponsorshipCNPq
dc.description.sponsorshipIDFAPESP: 2012/02270-2, 2012/16794-3, 2013/25327-2
dc.format.extent251-260
dc.identifierhttp://dx.doi.org/10.1007/s10787-017-0404-6
dc.identifier.citationInflammopharmacology. Basel, v. 26, n. 1, p. 251-260, 2018.
dc.identifier.doi10.1007/s10787-017-0404-6
dc.identifier.issn0925-4692
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54224
dc.identifier.wosWOS:000423397700021
dc.language.isoeng
dc.publisherSpringer Basel Ag
dc.relation.ispartofInflammopharmacology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectMesenchymal stromal cellsen
dc.subjectColitisen
dc.subjectInflammationen
dc.subjectIntestineen
dc.titleMesenchymal stromal cells modulate gut inflammation in experimental colitisen
dc.typeinfo:eu-repo/semantics/article
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