A randomized clinical comparison of OPTI-FREE EXPRESS and ReNu MultiPLUS multipurpose lens care solutions

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dc.contributor.authorLipener, Cesar
dc.contributor.authorCLASS Grp
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:52:23Z
dc.date.available2016-01-24T13:52:23Z
dc.date.issued2009-04-01
dc.description.abstractTo evaluate subjective symptoms and clinical signs of tolerability and comfort in silicone and non-silicone hydrogel contact lens (CL) wearers using two different multipurpose solution (MPS) CL care regimens.This was a randomized, double-masked, contralateral, crossover, multicenter (n=9) study. One hundred and eleven subjects were enrolled in the study, and were randomly assigned either silicone hydrogel CLs or non-silicone hydrogel CLs. Before wear, the CLs were randomly conditioned for at least 10 hours in a multipurpose disinfection solution (MPDS) preserved with either: Regimen 1-polyquaternium-1 0.001% and myristamidopropyl dimethylamine 0.0005% (POLYQUADA (R) and ALDOXA (R), respectively; OPTIFREE EXPRESSA (R) MPDS, Alcon Laboratories, Inc., Fort Worth, TX, USA); or Regimen 2-multipurpose solution preserved with polyhexamethylene biguanide 0.0001% (PHMB, ReNu MultiPLUSA (R) MPS, Bausch & Lomb, Rochester, NY, USA). the study had two in-office visits, 1 week apart. Subjects wore assigned CLs for approximately 4 hours at each visit. At each visit, subjects' eyes were examined before CL insertion and at 2 hours and 4 hours after insertion. Corneal staining type and area, conjunctival staining, conjunctival injection, subjective symptoms (tolerability), and comfort were evaluated.One hundred and five subjects (210 eyes) completed the study. the total corneal staining score of area and type were statistically significantly less in Regimen 1 than in Regimen 2 (P < 0.000001). the area of conjunctival staining was statistically significantly less in Regimen 1 than in Regimen 2 (P=0.03). No clinically significant hyperemia was observed for either regimen. Both tolerability (P=0.02) and patient preference (P=0.05) were in favor of Regimen 1.Statistically significant clinical differences were evident between the two CL care regimens when used with silicone and non-silicone hydrogel CLs. OPTI-FREE EXPRESS MPDS users showed less corneal and conjunctival staining and reported greater comfort and tolerability to the CL/solution combination than ReNu MultiPLUS MPS users.en
dc.description.affiliationUniversidade Federal de São Paulo, Contact Lens Dept, BR-04001083 Paraiso, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Contact Lens Dept, BR-04001083 Paraiso, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAlcon Laboratories, Inc., Brazil
dc.format.extent435-446
dc.identifierhttp://dx.doi.org/10.1007/s12325-009-0023-8
dc.identifier.citationAdvances in Therapy. New York: Springer, v. 26, n. 4, p. 435-446, 2009.
dc.identifier.doi10.1007/s12325-009-0023-8
dc.identifier.issn0741-238X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31411
dc.identifier.wosWOS:000266070900005
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofAdvances in Therapy
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectcomforten
dc.subjectconjunctival stainingen
dc.subjectcorneal stainingen
dc.subjectlens care productsen
dc.subjectmultipurpose solutionen
dc.subjectOPTI-FREEen
dc.subjectReNuen
dc.titleA randomized clinical comparison of OPTI-FREE EXPRESS and ReNu MultiPLUS multipurpose lens care solutionsen
dc.typeinfo:eu-repo/semantics/article
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