Glutamatergic neurotransmission in the inferior colliculus influences intrastriatal haloperidol-induced catalepsy

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dc.contributor.authorMedeiros, Priscila [UNIFESP]
dc.contributor.authorViana, Milena de Barros [UNIFESP]
dc.contributor.authorSilva, Regina Cláudia Barbosa da [UNIFESP]
dc.contributor.authorTonelli, Luan Castro [UNIFESP]
dc.contributor.authorMelo-Thomas, Liana [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionInst Neurociencias & Comportamento INEC
dc.date.accessioned2016-01-24T14:37:35Z
dc.date.available2016-01-24T14:37:35Z
dc.date.issued2014-07-15
dc.description.abstractThe inferior colliculus (IC) is an important midbrain relay station for the integration of descending and ascending auditory information. in addition, it has also been implicated in the processing of acoustic information of aversive nature, as well as in sensory-motor gating. There is evidence that glutamate-mediated mechanisms at the IC level influence haloperidol-induced catalepsy. the present study investigated the influence of glutamate-mediated mechanisms in the IC on catalepsy induced by intrastriatal microinjection of haloperidol (10 mu g/0.5 mu l). Male Wistar rats received bilateral intracollicular microinjections of the glutamate receptor agonist NMDA (10 or 20 nmol/0.5 mu l), the NMDA receptor antagonists MK-801 (15 or 30 nmol/0.5 mu l) or physiological saline (0.5 mu l), followed by bilateral microinjections of haloperidol (10 mu g/0.5 mu l) or vehicle (0.5 mu l) into the dorso-rostral or ventro-rostral striatum. the catalepsy test was performed positioning both forepaws of the rats on an elevated horizontal wooden bar and recording the time during which the animal remained in this position. the results showed that the administration of physiological saline in the IC followed by the microinjection of haloperidol in the dorso-rostral region of the striatum was not able to induce catalepsy. However, when the bilateral administration of NMDA into the IC was followed by microinjection of haloperidol into the dorso-rostral striatum, catalepsy was observed. the microinjection of haloperidol into the ventro-rostral striatum induced catalepsy, counteracted by previous administration of MK-801 into the IC. These findings suggest that glutamate-mediated mechanisms in the IC can influence the intrastriatal haloperidol-induced catalepsy and that the IC plays an important role as a sensorimotor interface. (C) 2014 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biociencias, BR-71060001 Santos, SP, Brazil
dc.description.affiliationInst Neurociencias & Comportamento INEC, BR-14040901 Ribeirao Preto, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biociencias, BR-71060001 Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2009/01437-8
dc.description.sponsorshipIDFAPESP: 2010/14446-2
dc.description.sponsorshipIDFAPESP: 2011/01409-4
dc.format.extent8-13
dc.identifierhttps://dx.doi.org/10.1016/j.bbr.2014.03.027
dc.identifier.citationBehavioural Brain Research. Amsterdam: Elsevier B.V., v. 268, p. 8-13, 2014.
dc.identifier.doi10.1016/j.bbr.2014.03.027
dc.identifier.issn0166-4328
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/37991
dc.identifier.wosWOS:000337650900002
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBehavioural Brain Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectCatalepsyen
dc.subjectGlutamateen
dc.subjectHaloperidolen
dc.subjectInferior colliclusen
dc.subjectNMDAen
dc.subjectStriatumen
dc.titleGlutamatergic neurotransmission in the inferior colliculus influences intrastriatal haloperidol-induced catalepsyen
dc.typeinfo:eu-repo/semantics/article
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