The soybean concentrated extract proliferates the vagina of adult rats

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dc.contributor.authorFerraz Carbonel, Adriana Aparecida [UNIFESP]
dc.contributor.authorPinheiro Baracat, Maria Candida [UNIFESP]
dc.contributor.authorSimoes, Ricardo Santos
dc.contributor.authorSimoes, Manuel Jesus [UNIFESP]
dc.contributor.authorBaracat, Edmund Chada
dc.contributor.authorSoares, Jose Maria [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T14:06:01Z
dc.date.available2016-01-24T14:06:01Z
dc.date.issued2011-01-01
dc.description.abstractObjective: the aim of this study was to evaluate changes induced on the vagina of ovariectomized rats after treatment with soybean concentrated extract or conjugated equine estrogens and the association of both drugs.Methods: We conducted an experimental study with 50 ovariectomized rats that were randomly divided into five equal groups of 10 animals: GI received vehicle, GII received soybean concentrated extract 46 mg/kg per day, GIII received soybean concentrated extract 120 mg/kg per day, GIV received conjugated equine estrogens 50 mu g/kg per day, and GV received conjugated equine estrogens 50 mu g/kg and soybean concentrated extract 46 mg/kg per day. the substances were administered by gavage during 21 consecutive days. After that, the animals were killed under anesthesia and the vagina was removed for histological and immunohistochemical analysis. Data were initially submitted to analysis of variance. Whenever a significant difference was detected, the study was complemented with the Tukey-Kramer test for multiple comparisons.Results: GII did not show any differences on the vaginal epithelium or collagen compared with GI. GIII presented an increase in vaginal epithelium and collagen amount. GIV had the highest amount of collagen and the signals of vaginal proliferation. GV did not show any additional effect compared with GIV.Conclusions: Our data suggest that a high dose of isoflavone-rich soy extract may have positive effects on the vaginal structures of ovariectomized rats, but this action is less than that of estrogen treatment on vaginal thickness. in addition, soy extract may not block the estrogen effect on vaginal tissue.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Gynecol, BR-04038031 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Morphol & Genet, BR-04038031 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Obstet & Gynecol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Gynecol, BR-04038031 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Morphol & Genet, BR-04038031 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Apoio a Universidade Federal de São Paulo (FAP/UNIFESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent93-101
dc.identifierhttp://dx.doi.org/10.1097/gme.0b013e3181e5ee25
dc.identifier.citationMenopause-the Journal of the North American Menopause Society. Philadelphia: Lippincott Williams & Wilkins, v. 18, n. 1, p. 93-101, 2011.
dc.identifier.doi10.1097/gme.0b013e3181e5ee25
dc.identifier.issn1072-3714
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33314
dc.identifier.wosWOS:000285684100019
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofMenopause-the Journal of the North American Menopause Society
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectSoy extracten
dc.subjectIsoflavonesen
dc.subjectConjugated estrogensen
dc.subjectVaginaen
dc.subjectCollagenen
dc.subjectRaten
dc.titleThe soybean concentrated extract proliferates the vagina of adult ratsen
dc.typeinfo:eu-repo/semantics/article
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