Effects of rimonabant on the development of single dose-induced behavioral sensitization to ethanol, morphine and cocaine in mice

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dc.contributor.authorMarinho, Eduardo Ary Villela
dc.contributor.authorOliveira-Lima, Alexandre Justo de
dc.contributor.authorSantos, Renan dos [UNIFESP]
dc.contributor.authorHollais, André Willian [UNIFESP]
dc.contributor.authorBaldaia, Marilia Araujo [UNIFESP]
dc.contributor.authorWuo-Silva, Raphael [UNIFESP]
dc.contributor.authorYokoyama, Thais Suemi [UNIFESP]
dc.contributor.authorTakatsu-Coleman, André Luis [UNIFESP]
dc.contributor.authorPatti, Camilla de Lima [UNIFESP]
dc.contributor.authorLongo, Beatriz Monteiro [UNIFESP]
dc.contributor.authorBerro, Laís Fernanda [UNIFESP]
dc.contributor.authorFrussa-Filho, Roberto [UNIFESP]
dc.contributor.institutionUniv Estadual Santa Cruz UESC
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:40:23Z
dc.date.available2016-01-24T14:40:23Z
dc.date.issued2015-04-03
dc.description.abstractRationale: the endocannabinoid system has been implicated in the neurobiological mechanism underlying drug addiction, especially the primary rewarding dopamine-dependent processes. Therefore, endocannabinoid receptor antagonists, such as the CB1 cannabinoid antagonist rimonabant, have been proposed as candidates for preventive addiction therapies.Objectives: Investigate the possible involvement of CB1 receptors in the development of behavioral sensitization to ethanol, morphine and cocaine in mice.Methods: We compared the effects of different doses of rimonabant (0.3, 1, 3 and 10 mg/kg) on spontaneous locomotor activity in the open-field, hyperlocomotion induced by acute administration of ethanol (1.8 g/kg), morphine (20 mg/kg) or cocaine (10 mg/kg) and on subsequent drug-induced locomotor sensitization using a two-injection protocol in mice. We also investigated a possible depressive-like effect of an acute rimonabant challenge at the highest dose and its potential anxiogenic property.Results: At the highest dose, rimonabant abolished ethanol-and cocaine-induced hyperlocomotion and behavioral sensitization without modifying spontaneous and central locomotor activity or inducing depressive-like behavior on the forced swim test in mice. the other doses of rimonabant also selectively blocked acute ethanol-induced central hyperlocomotion. Although rimonabant at 0.3 and 1 mg/kg potentiated the central hyperlocomotion induced by acute morphine injection, it was effective inattenuating morphine-induced behavioral sensitization at all doses.Conclusions: Because the neural basis of behavioral sensitization has been proposed to correspond to some components of addiction, our findings indicate that the endocannabinoid system might be involved in ethanol, cocaine and morphine abuse. (C) 2014 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniv Estadual Santa Cruz UESC, Dept Ciencias Saude, Ilheus, BA, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Dept Fisiol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Dept Farmacol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Dept Fisiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Dept Farmacol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Dept Psicobiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundo de Apoio ao Docente e Aluno (FADA)
dc.description.sponsorshipAssociacao Fundo de Incentivo a Pesquisa (AFIP)
dc.format.extent22-31
dc.identifierhttps://dx.doi.org/10.1016/j.pnpbp.2014.11.010
dc.identifier.citationProgress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 58, p. 22-31, 2015.
dc.identifier.doi10.1016/j.pnpbp.2014.11.010
dc.identifier.issn0278-5846
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/38992
dc.identifier.wosWOS:000349984000004
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofProgress in Neuro-psychopharmacology & Biological Psychiatry
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectBehavioral sensitizationen
dc.subjectCocaineen
dc.subjectEthanolen
dc.subjectMorphineen
dc.subjectRimonabanten
dc.titleEffects of rimonabant on the development of single dose-induced behavioral sensitization to ethanol, morphine and cocaine in miceen
dc.typeinfo:eu-repo/semantics/article
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