Urinary glycosaminoglycans in horse osteoarthritis. Effects of chondroitin sulfate and glucosamine

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dc.contributor.authorBaccarin, Raquel Yvonne Arantes
dc.contributor.authorMachado, Thais S. L.
dc.contributor.authorLopes-Moraes, Ana P.
dc.contributor.authorVieira, Fabiana A. C. [UNIFESP]
dc.contributor.authorMichelacci, Yara M. [UNIFESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:27:31Z
dc.date.available2016-01-24T14:27:31Z
dc.date.issued2012-08-01
dc.description.abstractOur objectives were to characterize the urinary excretion of glycosaminoglycans (GAGs) in horse osteoarthritis, and to investigate the effects of chondroitin sulfate (CS) and glucosamine (GlcN) upon the disease. Urinary GAGs were measured in 47 athletic horses, 20 healthy and 27 with osteoarthritis. the effects of CS and GlcN were investigated in mild osteoarthritis. in comparison to normal, urinary GAGs were increased in osteoarthritis, including mild osteoarthritis affecting only one joint. Treatment with CS + GlcN led to a long lasting increase in the urinary CS and keratan sulfate (KS), and significant improvement in flexion test of tarsocrural and metacarpophalangeal joints was observed. in conclusion, urinary CS and KS seems to reflect the turnover rates of cartilage matrix proteoglycans, and the measurement of these compounds could provide objective means of evaluating and monitoring joint diseases. (C) 2011 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv São Paulo, Dept Clin Med, Fac Med Vet & Zootecnia, BR-05508270 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, UNIFESP, Escola Paulista Med, Dept Bioquim, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, UNIFESP, Escola Paulista Med, Dept Bioquim, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipSociedade Paulista para o Desenvolvimento da Medicina (SPDM-FADA), São Paulo, SP, Brazil
dc.format.extent88-96
dc.identifierhttp://dx.doi.org/10.1016/j.rvsc.2011.08.009
dc.identifier.citationResearch in Veterinary Science. Oxford: Elsevier B.V., v. 93, n. 1, p. 88-96, 2012.
dc.identifier.doi10.1016/j.rvsc.2011.08.009
dc.identifier.issn0034-5288
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35140
dc.identifier.wosWOS:000305852200019
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofResearch in Veterinary Science
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectChondroitin sulfateen
dc.subjectGlucosamineen
dc.subjectUrinary glycosaminoglycanen
dc.subjectHorseen
dc.subjectKeratan sulfateen
dc.subjectOsteoarthritisen
dc.titleUrinary glycosaminoglycans in horse osteoarthritis. Effects of chondroitin sulfate and glucosamineen
dc.typeinfo:eu-repo/semantics/article
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