Preserved flow-mediated dilation but delayed time-to-peak diameter in individuals with metabolic syndrome

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dc.contributor.authorFernandes, Igor A.
dc.contributor.authorSales, Allan R. K.
dc.contributor.authorRocha, Natalia G.
dc.contributor.authorSilva, Bruno M. [UNIFESP]
dc.contributor.authorVianna, Lauro C.
dc.contributor.authorNobrega, Antonio C. L. da
dc.contributor.institutionUniversidade Federal Fluminense (UFF)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:37:34Z
dc.date.available2016-01-24T14:37:34Z
dc.date.issued2014-07-01
dc.description.abstractIntroduction: Inconsistent evidences of the metabolic syndrome (MetS) impact on vascular reactivity raise questions on flow-mediated dilation (FMD) discriminatory power for disturbances induced by this clustering of risk factors. Previous reports, however, suggest that covariates such as the follow-up of the artery diameter changes, the arterial size and shear stress affect FMD responses and consequently its discriminatory power for distinctive clinical profiles.Objective: To determine the impact of MetS on traditional, arterial size-and shear-rate-adjusted FMD, the follow-up-derived time-to-peak diameter (TP), as well as their power for discriminating subjects with this clustering of risk factors from a sample of healthy individuals.Methods: Twenty-one MetS and ten healthy subjects underwent an assessment of endothelial function via FMD.Results: Traditional and allometrically scaled FMD did not differ between groups (P>0.05) as well as the approach in which the covariate was the peak diameter shear rate. in the existence of MetS, TP was longer (67.7 +/- 16.4 s versus healthy 42.1 +/- 16.3 s, P = 0.001). ROC curve analysis indicated that TP (AUC = 0.871 [95% CI, 0.718-1.000]) had greater power of discrimination for MetS than FMD approaches. in addition, TP presented a moderate and significant association with sE-selectin (r = 0.458, P = 0.048).Conclusion: Time-to-peak diameter (TP) rather than FMD distinguished MetS from a healthy profile. Therefore, at least in subjects with MetS, TP may provide insights into the impact of this clustering of risk factors on the vascular phenotype.en
dc.description.affiliationUniv Fed Fluminense, Lab Exercise Sci, Dept Physiol & Pharmacol, BR-24210130 Niteroi, RJ, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Exercise Physiol Sect, Dept Physiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Exercise Physiol Sect, Dept Physiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)
dc.description.sponsorshipBrazilian Financing Agency of Studies and Projects (FINEP)
dc.format.extent270-276
dc.identifierhttp://dx.doi.org/10.1111/cpf.12092
dc.identifier.citationClinical Physiology and Functional Imaging. Hoboken: Wiley-Blackwell, v. 34, n. 4, p. 270-276, 2014.
dc.identifier.doi10.1111/cpf.12092
dc.identifier.issn1475-0961
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37970
dc.identifier.wosWOS:000340569600004
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofClinical Physiology and Functional Imaging
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectdoppleren
dc.subjectendothelial functionen
dc.subjecthyperaemiaen
dc.subjectshear stressen
dc.subjectvascular reactivityen
dc.titlePreserved flow-mediated dilation but delayed time-to-peak diameter in individuals with metabolic syndromeen
dc.typeinfo:eu-repo/semantics/article
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