Human tissue kallikreins 3 and 5 can act as plasminogen activator releasing active plasmin

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dc.contributor.authorSouza, Lucas R. de
dc.contributor.authorMelo, Pollyana Maria Saud [UNIFESP]
dc.contributor.authorPaschoalin, Thaysa [UNIFESP]
dc.contributor.authorCarmona, Adriana Karaoglanovic [UNIFESP]
dc.contributor.authorKondo, Marcia Yuri [UNIFESP]
dc.contributor.authorHirata, Izaura Yoshico [UNIFESP]
dc.contributor.authorBlaber, Michael
dc.contributor.authorTersariol, Ivarne Luis dos Santos [UNIFESP]
dc.contributor.authorTakatsuka, Joyce
dc.contributor.authorJuliano, Maria Aparecida [UNIFESP]
dc.contributor.authorJuliano, Luiz [UNIFESP]
dc.contributor.authorGomes, Roseli A.
dc.contributor.authorPuzer, Luciano
dc.contributor.institutionUniversidade Federal do ABC (UFABC)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionFlorida State Univ
dc.contributor.institutionUniv Mogi das Cruzes
dc.contributor.institutionUniv Fed Triangulo Mineiro
dc.date.accessioned2016-01-24T14:31:34Z
dc.date.available2016-01-24T14:31:34Z
dc.date.issued2013-04-12
dc.description.abstractHuman tissue kallikreins (KLKs) are a group of serine proteases found in many tissues and biological fluids and are differentially expressed in several specific pathologies. Here, we present evidences of the ability of these enzymes to activate plasminogen. Kallikreins 3 and 5 were able to induce plasmin activity after hydrolyzing plasminogen, and we also verified that plasminogen activation was potentiated in the presence of glycosaminoglycans compared with plasminogen activation by tPA. This finding can shed new light on the plasminogen/plasmin system and its involvement in tumor metastasis, in which kallikreins appear to be upregulated. (C) 2013 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniv Fed ABC, Ctr Ciencias Nat & Humanas, Santo Andre, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biofis, Sao Carlos, SP, Brazil
dc.description.affiliationFlorida State Univ, Coll Med, Dept Biomed Sci, Tallahassee, FL 32306 USA
dc.description.affiliationUniv Mogi das Cruzes, Ctr Interdisciplinar Invest Bioquim, São Paulo, Brazil
dc.description.affiliationUniv Fed Triangulo Mineiro, Inst Ciencias Biol & Nat, Uberaba, MG, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biofis, Sao Carlos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.description.sponsorshipIDFAPESP: Proc 2011/51297-8
dc.description.sponsorshipIDCNPq: 312701/2009-8
dc.format.extent333-337
dc.identifierhttp://dx.doi.org/10.1016/j.bbrc.2013.03.001
dc.identifier.citationBiochemical and Biophysical Research Communications. San Diego: Academic Press Inc Elsevier Science, v. 433, n. 3, p. 333-337, 2013.
dc.identifier.doi10.1016/j.bbrc.2013.03.001
dc.identifier.fileWOS000318190400012.pdf
dc.identifier.issn0006-291X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36204
dc.identifier.wosWOS:000318190400012
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBiochemical and Biophysical Research Communications
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectPlasminogenen
dc.subjectPlasminen
dc.subjectKallikreinen
dc.subjectProteaseen
dc.titleHuman tissue kallikreins 3 and 5 can act as plasminogen activator releasing active plasminen
dc.typeinfo:eu-repo/semantics/article
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