Long-Term Astroglial Reaction and Neuronal Plasticity in the Subcortical Visual Pathways After a Complete Ablation of Telencephalon in Pigeons (Columba livia)

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dc.contributor.authorCerutti, Suzete Maria [UNIFESP]
dc.contributor.authorGomide, Vania Canterucci
dc.contributor.authorFerrari, Elenis A. de Moraes
dc.contributor.authorChadi, Gerson
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:52:05Z
dc.date.available2016-01-24T13:52:05Z
dc.date.issued2009-01-01
dc.description.abstractThis paper analyzes the astroglial and neuronal responses in subtelencephalic structures, following a bilateral ablation of the telencephalon in the Columba livia pigeons. Control birds received a sham operation. Four months later the birds were sacrificed and their brains processed for glial fribillary acid protein (GFAP) and neurofilament immunohistochemistry, markers for astrocytes and neurons, respectively. Computer-assisted image analysis was employed for quantification of the immunoreactive labeling in the nucleus rotundus (N.Rt) and the optic tectum (OT) of the birds. An increased number of GFAP immunoreactive astrocytes were found in several subregions of the N.Rt (p .001), as well as in layers 1, 2cd, 3, and 6 of the OT (p .001) of the lesioned animals. Neurofilament immunoreactivity decreased massively in the entire N.Rt of the lesioned birds; however, remaining neurons with healthy aspect showing large cytoplasm and ramified branches were detected mainly in the periphery of the nucleus. in view of the recently described paracrine neurotrophic properties of the activated astrocytes, the data of the present study may suggest a long-lasting neuroglial interaction in regions of the lesioned bird brain far from injury. Such events may trigger neuronal plasticity in remaining brain structures that may lead spontaneous behavior recovery as the one promoted here even after a massive injury.en
dc.description.affiliationUniv São Paulo, Dept Neurol, Neuroregenerat Ctr, Sch Med, BR-01246903 São Paulo, Brazil
dc.description.affiliationUniv Estadual Campinas, Inst Biol, Dept Physiol & Biophys, Lab Neural Syst & Behav, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ciencias Biol, SMC, BR-09972270 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ciencias Biol, SMC, BR-09972270 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent384-403
dc.identifierhttp://dx.doi.org/10.1080/00207450802480291
dc.identifier.citationInternational Journal of Neuroscience. London: Informa Healthcare, v. 119, n. 3, p. 384-403, 2009.
dc.identifier.doi10.1080/00207450802480291
dc.identifier.issn0020-7454
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31187
dc.identifier.wosWOS:000262108500008
dc.language.isoeng
dc.publisherInforma Healthcare
dc.relation.ispartofInternational Journal of Neuroscience
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dc.subjectastrocyteen
dc.subjectGFAPen
dc.subjectimage analysisen
dc.subjectimmunohistochemistryen
dc.subjectoptic tectumen
dc.subjectplasticityen
dc.titleLong-Term Astroglial Reaction and Neuronal Plasticity in the Subcortical Visual Pathways After a Complete Ablation of Telencephalon in Pigeons (Columba livia)en
dc.typeinfo:eu-repo/semantics/article
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