Genome-wide investigation of schizophrenia associated plasma Ndel1 enzyme activity

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dc.citation.volume172
dc.contributor.authorGadelha, Ary [UNIFESP]
dc.contributor.authorColeman, Jonathan
dc.contributor.authorBreen, Gerome
dc.contributor.authorMazzoti, Diego Robles [UNIFESP]
dc.contributor.authorYonamine, Camila Miyagui [UNIFESP]
dc.contributor.authorPellegrino, Renata
dc.contributor.authorOta, Vanessa Kiyomi [UNIFESP]
dc.contributor.authorBelangero, Sintia Iole [UNIFESP]
dc.contributor.authorGlessner, Joseph
dc.contributor.authorSleiman, Patrick
dc.contributor.authorHakonarson, Hakon
dc.contributor.authorHayashi, Mirian Akemi Furuie [UNIFESP]
dc.contributor.authorBressan, Rodrigo Affonseca [UNIFESP]
dc.coverageAmsterdam
dc.date.accessioned2020-07-22T13:23:18Z
dc.date.available2020-07-22T13:23:18Z
dc.date.issued2016
dc.description.abstractNdel1 is a DISC1-interacting oligopeptidase that cleaves in vitro neuropeptides as neurotensin and bradykinin, and which has been associated with both neuronal migration and neurite outgrowth. We previously reported that plasma Ndel1 enzyme activity is lower in patients with schizophrenia (SCZ) compared to healthy controls (HCs). To our knowledge, no previous study has investigated the genetic factors associated with the plasma Ndel1 enzyme activity. In the current analyses, samples from 83 SCZ patients and 92 control subjects that were assayed for plasma Ndel1 enzyme activity were genotyped on Illumina Omni Express arrays. A genetic relationship matrix using genome-wide information was then used for ancestry correction, and association statistics were calculated genome-wide. Ndel1 enzyme activity was significantly lower in patients with SCZ (t=4.9en
dc.description.abstractp < 0.001) and was found to be associated with CAMK1D, MAGI2, CCDC25, and GABGR3, at a level of suggestive significance (p < 10(-6)), independent of the clinical status. Then, we performed a model to investigate the observed differences for case/control measures. 2 SNPs at region 1p22.2 reached the p < 10(-7) level. ZFPM2 and MAD1L1 were the only two genes with more than one hit at 10-6 order of p value. Therefore, Ndel1 enzyme activity is a complex trait influenced by many different genetic variants that may contribute to SCZ physiopathology. (C) 2016 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Fed Sao Paulo UNIFESP EPM, Dept Psychiat, Ed Pesquisas 2,Rua Pedro de Toledo 669,3rd Floor, BR-04039032 Sao Paulo, SP, Brazil
dc.description.affiliationKings Coll London, Inst Psychiat Psychol & Neurosci, MRC, Social Genet & Dev Psychiat Ctr, London WC2R 2LS, England
dc.description.affiliationUNIFESP EPM, Dept Psychobiol, Sao Paulo, Brazil
dc.description.affiliationUNIFESP EPM, Dept Pharmacol, Sao Paulo, Brazil
dc.description.affiliationChildrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA
dc.description.affiliationUNIFESP EPM, Dept Morphol & Genet, Sao Paulo, Brazil
dc.description.affiliationUniv Penn, Dept Pediat, Perelman Sch Med, Philadelphia, PA 19104 USA
dc.description.affiliationKings Coll London, Maudsley Hosp, Natl Inst Hlth Res, Biomed Res Ctr Mental Hlth, London WC2R 2LS, England
dc.description.affiliationKings Coll London, Inst Psychiat Psychol & Neurosci, London WC2R 2LS, England
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP EPM, Dept Psychiat, Ed Pesquisas 2,Rua Pedro de Toledo 669,3rd Floor, BR-04039032 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUNIFESP EPM, Dept Psychobiol, Sao Paulo, Brazil
dc.description.affiliationUnifespUNIFESP EPM, Dept Pharmacol, Sao Paulo, Brazil
dc.description.affiliationUnifespUNIFESP EPM, Dept Morphol & Genet, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipSao Paulo Research Foundation (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo - FAPESP)
dc.description.sponsorshipNational Council of Technological and Scientific Development (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico - CNPq)
dc.description.sponsorshipIDFAPESP: 2011/50740-5
dc.description.sponsorshipIDFAPESP: 2013/13392-4
dc.description.sponsorshipIDFAPESP: 2009/51587-6
dc.description.sponsorshipIDFAPESP: 2012/08941-6
dc.description.sponsorshipIDCNPq: 477760/2010-4
dc.description.sponsorshipIDCNPq: 557753/2010-4
dc.description.sponsorshipIDCNPq: 508113/2010-5
dc.description.sponsorshipIDCNPq: 311815/2012-0
dc.description.sponsorshipIDCNPq: 475739/2013-2
dc.format.extent60-67
dc.identifierhttp://dx.doi.org/10.1016/j.schres.2016.01.043
dc.identifier.citationSchizophrenia Research. Amsterdam, v. 172, p. 60-67, 2016.
dc.identifier.doi10.1016/j.schres.2016.01.043
dc.identifier.issn0920-9964
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56156
dc.identifier.wosWOS:000373528100010
dc.language.isoeng
dc.publisherElsevier Science Bv
dc.relation.ispartofSchizophrenia Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectNdel1en
dc.subjectSchizophreniaen
dc.subjectGWASen
dc.subjectBiomarkeren
dc.subjectEnzyme activityen
dc.titleGenome-wide investigation of schizophrenia associated plasma Ndel1 enzyme activityen
dc.typeinfo:eu-repo/semantics/article
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