Estrogen receptor alpha polymorphism and susceptibility to uterine leiomyoma

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dc.contributor.authorVillanova, Fabiola E.
dc.contributor.authorAndrade, Priscila M.
dc.contributor.authorOtsuka, Audrey Y.
dc.contributor.authorGomes, Mariano T. V.
dc.contributor.authorLeal, Elcio S.
dc.contributor.authorCastro, Rodrigo A.
dc.contributor.authorGirao, Manoel J. B. C.
dc.contributor.authorNishimura, Eddy
dc.contributor.authorBaracat, Edmund C.
dc.contributor.authorSilva, Ismael D. C. G.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionPerola Byington Hosp
dc.date.accessioned2016-01-24T12:41:34Z
dc.date.available2016-01-24T12:41:34Z
dc.date.issued2006-11-01
dc.description.abstractUterine leiomyoma is the most frequent pelvic tumor found in female genital tract. Some studies have suggested an association between single nucleotide polymorphisms (SNPs) in estrogen receptors genes with susceptibility in developing uterine leiomyoma. in this work, we estimated the frequency of two SNPs: one located in the intron 1 (rs9322331) and other in the exon 1 (rs17847075) of the estrogen receptor alpha (ESR1) gene in 125 women with uterine leiomyoma and 125 healthy women. To do this we used a PCR-RFLP method with Mspl and HaeIII restriction enzymes to respectively detect C/T SNPs in the intron 1 and in the exon 1 of ESR1. To our knowledge this is the first study aimed to investigate the association of ESR1 SNPs with the risk of developing uterine leiomyoma in Brazilian women. Our results showed that the allele frequencies of the exon 1 and the intron 1 of the ESR1 gene did not differ between cases and controls (P=0.325 and 0.175, respectively). Furthermore, our findings provided little support for the association of these SNPs on ESR1 with leiomyoma. However, we found that the SNP in the intron 1 of the ESR1 gene was underrepresented in the Brazilian female population.(C) 2006 Elsevier Inc. All rights reserved.en
dc.description.affiliationUNIFESP, Dept Gynecol, Mol Gynecol Lab, BR-04039032 São Paulo, Brazil
dc.description.affiliationUNIFESP, Dept Med, BR-04039032 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Urol, São Paulo, Brazil
dc.description.affiliationPerola Byington Hosp, São Paulo, Brazil
dc.description.affiliationUnifespUNIFESP, Dept Gynecol, Mol Gynecol Lab, BR-04039032 São Paulo, Brazil
dc.description.affiliationUnifespUNIFESP, Dept Med, BR-04039032 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent960-965
dc.identifierhttp://dx.doi.org/10.1016/j.steroids.2006.07.005
dc.identifier.citationSteroids. New York: Elsevier B.V., v. 71, n. 11-12, p. 960-965, 2006.
dc.identifier.doi10.1016/j.steroids.2006.07.005
dc.identifier.issn0039-128X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29240
dc.identifier.wosWOS:000242060200006
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofSteroids
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectuterine leiomyomaen
dc.subjectestrogen receptor alphaen
dc.subjectBrazilian womenen
dc.subjectpolymorphismen
dc.subjectSNPen
dc.subjectgenotypesen
dc.titleEstrogen receptor alpha polymorphism and susceptibility to uterine leiomyomaen
dc.typeinfo:eu-repo/semantics/article
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