Randomized Trial on the Effect of Sevoflurane on Polypropylene Membrane Oxygenator Performance

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dc.contributor.authorNeto, Caetano Nigro
dc.contributor.authorArnoni, Renato
dc.contributor.authorRida, Bilal Smaili
dc.contributor.authorLandoni, Giovanni
dc.contributor.authorTardelli, Maria Angela [UNIFESP]
dc.contributor.institutionDante Pazzanese Inst Cardiol
dc.contributor.institutionIst Sci San Raffaele
dc.contributor.institutionMaieut Fdn
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:34:32Z
dc.date.available2016-01-24T14:34:32Z
dc.date.issued2013-10-01
dc.description.abstractObjectives: Volatile anesthetics have cardioprotective properties that improve clinically relevant outcomes in cardiac surgery, and can be used during cardiopulmonary bypass (CPB) through adapted calibrated vaporizers together with air and oxygen (O-2). the effect of volatile agents on the membrane oxygenator is unknown. the aim of this study was to evaluate, for the first time, the performance of semiporous polypropylene membrane oxygenators after the use of sevoflurane vaporized during CPB in cardiac surgery.Design: A prospective, randomized, controlled trial.Setting: Teaching hospital.Participants: Thirty-two consecutive patients scheduled to undergo coronary artery bypass graft with CPB.Interventions: Patients were allocated randomly to receive either a volatile anesthetic (sevoflurane 1%-3%, 16 patients) or an intravenous hypnotic (midazolam, 16 patients) during CPB. After surgery, the membrane oxygenators used during CPB were tested with regard to O-2 transfer, carbon dioxide transfer, and pressure drop.Measurements and Main Results: the authors observed no protocol deviation or crossover. the performance of the membrane oxygenator was similar between the 2 groups, as documented by O-2 transfer (55 +/- 6.4 mL/min/L in the sevoflurane group versus 57 +/- 4.7 mL/min/L in the midazolam group, p = 0.4), carbon dioxide transfer, and pressure drop.Conclusions: the use of sevoflurane during CPB in cardiac surgery does not affect membrane oxygenator performance. (C) 2013 Elsevier Inc. All rights reserved.en
dc.description.affiliationDante Pazzanese Inst Cardiol, São Paulo, Brazil
dc.description.affiliationIst Sci San Raffaele, Anesthesia & Intens Care Dept, Milan, Italy
dc.description.affiliationMaieut Fdn, Milan, Italy
dc.description.affiliationUniversidade Federal de São Paulo, Anesthesia & Intens Care Dept, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Anesthesia & Intens Care Dept, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent903-907
dc.identifierhttp://dx.doi.org/10.1053/j.jvca.2012.12.012
dc.identifier.citationJournal of Cardiothoracic and Vascular Anesthesia. Philadelphia: W B Saunders Co-Elsevier Inc, v. 27, n. 5, p. 903-907, 2013.
dc.identifier.doi10.1053/j.jvca.2012.12.012
dc.identifier.issn1053-0770
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36845
dc.identifier.wosWOS:000325055100012
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Cardiothoracic and Vascular Anesthesia
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectcardiopulmonary bypassen
dc.subjectanesthesiaen
dc.subjectdrugsen
dc.subjectevaluationen
dc.subjectmembrane oxygenatoren
dc.subjectgas transferen
dc.subjectoxygenen
dc.subjectsevofluraneen
dc.titleRandomized Trial on the Effect of Sevoflurane on Polypropylene Membrane Oxygenator Performanceen
dc.typeinfo:eu-repo/semantics/article
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