Hippocampal atrophy and memory dysfunction in patients with juvenile myoclonic epilepsy

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dc.contributor.authorLin, Katia [UNIFESP]
dc.contributor.authorAraujo Filho, Gerardo Maria de [UNIFESP]
dc.contributor.authorPascalicchio, Tatiana Frascareli [UNIFESP]
dc.contributor.authorSilva, Ivaldo [UNIFESP]
dc.contributor.authorSilva Tudesco, Ivanda Souza [UNIFESP]
dc.contributor.authorBittar Guaranha, Mirian Salvadori [UNIFESP]
dc.contributor.authorCarrete Junior, Henrique [UNIFESP]
dc.contributor.authorJackowski, Andrea Parolin [UNIFESP]
dc.contributor.authorTargas Yacubian, Elza Marcia [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionHGCR
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T14:34:32Z
dc.date.available2016-01-24T14:34:32Z
dc.date.issued2013-10-01
dc.description.abstractJuvenile myoclonic epilepsy (JME) is a well-defined idiopathic generalized epilepsy (IGE) syndrome, being the most common IGE in adults and accounting for 5-11% of patients with epilepsy. While neuropsychological and neuroimaging studies have discussed the thalamofrontal dysfunction as the major pathophysiologic mechanism of JME, investigation on memory is scarce in patients with JME, with lack of objective assessments addressing common complaints and daily difficulties such as recalling telephone numbers, messages to pass on, and taking antiepileptic drugs regularly. the aim of this study was to objectively assess memory deficits in a group of patients with JME using neuropsychological examination combined with structural MRI of the hippocampi. After informed consent, a cohort of 56 consecutive patients with JME (29 males; mean age +/- SD = 26.5 +/- 9.01 years; range = 14.0-55.0 years) was included. the control group consisted of 42 healthy volunteers (18 males; mean age +/- SD = 31.0 +/- 8.54 years; range = 20.0-56.0 years) without a family history of neuropsychiatric disorders. Patients and controls were submitted to a MRI and to a neuropsychological assessment, and comparisons between groups were performed, as well as a correlation study between hippocampal atrophy and neuropsychological performance in a group of patients with JME. the level of statistical significance was set at p < 0.05. Significant hippocampal atrophy among patients with JME was observed, which was correlated with memory dysfunctions. the present findings reinforce the existence of functional-anatomic ictogenic networks that are not limited to frontal lobes, providing further support towards the concept of 'system epilepsies' in JME. (C) 2013 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP EPM, Unidade Pesquisa & Tratamento Epilepsias UNIPETE, São Paulo, Brazil
dc.description.affiliationHGCR, Ctr Cirurgia Epilepsia Santa Catarina CEPESC, Florianopolis, SC, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP EPM, Dept Psiquiatria, LiNC, São Paulo, Brazil
dc.description.affiliationFac Med Sao Jose do Rio Preto FAMERP, Dept Psiquiatria & Psicol Med, Sao Jose Do Rio Preto, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP EPM, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP EPM, Dept Diagnost Imagem, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP EPM, Unidade Pesquisa & Tratamento Epilepsias UNIPETE, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP EPM, Dept Psiquiatria, LiNC, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP EPM, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP EPM, Dept Diagnost Imagem, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent247-251
dc.identifierhttp://dx.doi.org/10.1016/j.yebeh.2013.06.034
dc.identifier.citationEpilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 29, n. 1, p. 247-251, 2013.
dc.identifier.doi10.1016/j.yebeh.2013.06.034
dc.identifier.issn1525-5050
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36842
dc.identifier.wosWOS:000324241300042
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofEpilepsy & Behavior
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectJuvenile myoclonic epilepsyen
dc.subjectMemory dysfunctionsen
dc.subjectHippocampal atrophyen
dc.subjectMagnetic resonance imagingen
dc.subjectNeuropsychological testingen
dc.titleHippocampal atrophy and memory dysfunction in patients with juvenile myoclonic epilepsyen
dc.typeinfo:eu-repo/semantics/article
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