Androgen Receptor CAG Repeat Polymorphism Is Not Associated With Erectile Dysfunction Complaints, Gonadal Steroids, and Sleep Parameters: Data From a Population-Based Survey

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dc.contributor.authorAndersen, Monica Levy [UNIFESP]
dc.contributor.authorGuindalini, Camila [UNIFESP]
dc.contributor.authorSantos-Silva, Rogerio [UNIFESP]
dc.contributor.authorBittencourt, Lia Rita Azeredo [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:17:08Z
dc.date.available2016-01-24T14:17:08Z
dc.date.issued2011-09-01
dc.description.abstractErectile dysfunction (ED) can be affected by androgen levels, which exert their action through the androgen receptor (AR). Androgenic action has been demonstrated to inversely correlate with a polymorphic trinucleotide CAG repeat region in the AR gene. We conducted an epidemiologic study to determine the potential association between the CAG repeat polymorphism of the AR gene and ED complaints, gonadal steroids, and sleep parameters in a large population-based sample in São Paulo, Brazil. AR CAG repeat was genotyped in 79 men with ED complaints and in 340 controls. Sleep and hormonal profiles were measured in all men. There was no association between the AR CAG repeat polymorphism and ED complaints. Moreover, there was no significant correlation among free and total testosterone, estradiol, follicle-stimulating hormone, and luteinizing hormone levels, as well as sleep parameters with the CAG repeat length, when evaluating the population as a whole, as well as subdivided into ED and control groups independently. the results were not affected when the data were analyzed in quartiles, divided by the median of the sample, or after correction for population stratification. AR CAG repeat polymorphism is not associated with ED complaints, gonadal steroids, and sleep parameters in men from a population-based sample in Brazil.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAssociacao Fundo de Incentivo a Pesquisa and Fundo de Amparo a Pesquisa do Estado de São Paulo
dc.description.sponsorshipCentro de Pesquisa, Inovacao e Difusao
dc.description.sponsorshipCentro Nacional de Desenvolvimento Cientifico e Tecnologico
dc.description.sponsorshipIDAssociacao Fundo de Incentivo a Pesquisa and Fundo de Amparo a Pesquisa do Estado de São Paulo: 07/50525-1
dc.description.sponsorshipIDCentro de Pesquisa, Inovacao e Difusao: 98/14303-3
dc.format.extent524-529
dc.identifierhttp://dx.doi.org/10.2164/jandrol.110.012013
dc.identifier.citationJournal of Andrology. Lawrence: Amer Soc Andrology, Inc, v. 32, n. 5, p. 524-529, 2011.
dc.identifier.doi10.2164/jandrol.110.012013
dc.identifier.issn0196-3635
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33993
dc.identifier.wosWOS:000293551300012
dc.language.isoeng
dc.publisherAmer Soc Andrology, Inc
dc.relation.ispartofJournal of Andrology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHormoneen
dc.subjectreproductive geneticsen
dc.subjecttestosteroneen
dc.subjectCAG polymorphismen
dc.subjectLHen
dc.subjectFSHen
dc.titleAndrogen Receptor CAG Repeat Polymorphism Is Not Associated With Erectile Dysfunction Complaints, Gonadal Steroids, and Sleep Parameters: Data From a Population-Based Surveyen
dc.typeinfo:eu-repo/semantics/article
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