Gene polymorphism of interleukin 1 and 8 in chronic gastritis patients infected with Helicobacter pylori

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dc.contributor.authorCaleman Neto, Agostinho
dc.contributor.authorRasmussen, Lucas Trevizani [UNIFESP]
dc.contributor.authorLábio, Roger Willian de
dc.contributor.authorQueiroz, Valdeir F de
dc.contributor.authorSmith, Marilia de Arruda Cardoso [UNIFESP]
dc.contributor.authorViani, Gustavo A
dc.contributor.authorPayão, Spencer Luiz Marques [UNIFESP]
dc.contributor.institutionMarília Medical School FAMEMA Blood Center Department of Genetics
dc.contributor.institutionSacred Heart University
dc.contributor.institutionMarília Medical School Department of Digestive System Surgery
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionMarília Medical School Department of Radiotherapy and Oncology
dc.contributor.institutionFAMEMA Hemocentro Laboratório de Genética
dc.date.accessioned2015-06-14T13:47:06Z
dc.date.available2015-06-14T13:47:06Z
dc.date.issued2014-05-20
dc.description.abstractBackground: Epidemiological investigations have indicated that Helicobacter pylori induces inflammation in the gastric mucosa regulated by several interleukins. The genes IL1B and IL8 are suggested as key factors in determining the risk of gastritis. The aim of this paper was to evaluate the association of gene polymorphism of interleukin-1 and interleukin-8 with chronic gastrits in H. pylori infected patients. A total of 60 patients underwent endoscopic procedure. Biopsy samples were collected for urease test, histopathological and molecular exams. The DNA of theses samples was extracted for detection of H. pylori and analysis of the genes mentioned above. Patients with gastritis had a higher frequency of H. pylori-positive samples. Result: H. pylori was detected in 30/60 patients (50%) by PCR. As for polymorphism of interleukin 8 (-251) gene we observed a statistical difference when analyzed TA (p = 0.039) and TT (p = 0.047) genotypes. In the IL1B31 there was a statistical difference in TT (p = 0.01) genotype and in theIL1B-511 there wasn’t any statistical difference. Conclusion: Our results suggest a strong correlation between the presence of chronic gastritis and infection byH. pylori and that IL1B-31TT and IL8-251TT genotypes appear to act as protective factors againstH. pylori infection while IL8-251TA genotype may comprise a risk factor for infection with this bacterium.en
dc.description.affiliationMarília Medical School FAMEMA Blood Center Department of Genetics
dc.description.affiliationSacred Heart University
dc.description.affiliationMarília Medical School Department of Digestive System Surgery
dc.description.affiliationFederal University of São Paulo Department of Morphology
dc.description.affiliationMarília Medical School Department of Radiotherapy and Oncology
dc.description.affiliationFAMEMA Hemocentro Laboratório de Genética
dc.description.affiliationUnifespUNIFESP, Department of Morphology
dc.description.sourceSciELO
dc.format.extent1-5
dc.identifierhttp://dx.doi.org/10.1186/1678-9199-20-17
dc.identifier.citationJournal of Venomous Animals and Toxins including Tropical Diseases. Centro de Estudos de Venenos e Animais Peçonhentos - CEVAP, Universidade Estadual Paulista - UNESP, v. 20, p. 1-5, 2014.
dc.identifier.doi10.1186/1678-9199-20-17
dc.identifier.fileS1678-91992014000200327.pdf
dc.identifier.issn1678-9199
dc.identifier.scieloS1678-91992014000200327
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/8384
dc.language.isoeng
dc.publisherCentro de Estudos de Venenos e Animais Peçonhentos - CEVAP, Universidade Estadual Paulista - UNESP
dc.relation.ispartofJournal of Venomous Animals and Toxins including Tropical Diseases
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHelicobacter pylorien
dc.subjectPolymorphismen
dc.subjectInterleukinen
dc.titleGene polymorphism of interleukin 1 and 8 in chronic gastritis patients infected with Helicobacter pylorien
dc.typeinfo:eu-repo/semantics/article
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