ON THE VERGE OF A RESPIRATORY-TYPE PANIC ATTACK: SELECTIVE ACTIVATIONS OF ROSTROLATERAL AND CAUDOVENTROLATERAL PERIAQUEDUCTAL GRAY MATTER FOLLOWING SHORT-LASTING ESCAPE TO A LOW DOSE OF POTASSIUM CYANIDE

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dc.citation.volume348
dc.contributor.authorTorres Muller, Claudia Janaina
dc.contributor.authorQuintino-Dos-Santos, Jeyce Willig
dc.contributor.authorSchimitel, Fagna Giacomin
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorBeijamini, Vanessa
dc.contributor.authorCanteras, Newton Sabino
dc.contributor.authorSchenberg, Luiz Carlos
dc.coverageOxford
dc.date.accessioned2020-07-17T14:02:16Z
dc.date.available2020-07-17T14:02:16Z
dc.date.issued2017
dc.description.abstractIntravenous injections of potassium cyanide (KCN) both elicit escape by its own and facilitate escape to electrical stimulation of the periaqueductal gray matter (PAG). Moreover, whereas the KCN-evoked escape is potentiated by CO2, it is suppressed by both lesions of PAG and clinically effective treatments with panicolytics. These and other data suggest that the PAG harbors a hypoxiasensitive alarm system the activation of which could both precipitate panic and render the subject hypersensitive to CO2. Although prior c-Fos immunohistochemistry studies reported widespread activations of PAG following KCN injections, the employment of repeated injections of high doses of KCN (> 60 mu g) in anesthetized rats compromised both the localization of KCN-responsive areas and their correlation with escape behavior. Accordingly, here we compared the brainstem activations of saline-injected controls (air/saline) with those produced by a single intravenous injection of 40-mu g KCN (air/KCN), a 2-min exposure to 13% CO2 (CO2/saline), or a combined stimulus (CO2/KCN). Behavioral effects of KCN microinjections into the PAG were assessed as well. Data showed that whereas the KCN microinjections were ineffective, KCN intravenous injections elicited escape in all tested rats. Moreover, whereas the CO2 alone was ineffective, it potentiated the KCNevoked escape. Compared to controls, the nucleus tractus solitarius was significantly activated in both CO2/saline and CO2/KCN groups. Additionally, whereas the laterodorsal tegmental nucleus was activated by all treatments, the rostrolateral and caudoventrolateral PAG were activated by air/KCN only. Data suggest that the latter structures are key components of a hypoxia-sensitive suffocation alarm which activation may trigger a panic attack. (C) 2017 IBRO. Published by Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Fed Espirito Santo, Dept Physiol Sci, Vitoria, ES, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychobiol, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Espirito Santo, Dept Pharmaceut Sci, Vitoria, ES, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Biomed Sci, Dept Anat, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psychobiol, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCAPES
dc.description.sponsorshipCNPq
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico/Fundacao de Amparo a Pesquisa do Espirito Santo (CNPq/FAPES)
dc.description.sponsorshipUniversidade Federal do Espirito Santo/Associacao Fundo de Incentivo a Pesquisa (UFES/AFIP)
dc.description.sponsorshipIDCNPq/FAPES: 55203345/11
dc.description.sponsorshipIDUFES/AFIP: 23068.020409/2010-43
dc.format.extent228-240
dc.identifierhttp://dx.doi.org/10.1016/j.neuroscience.2017.02.022
dc.identifier.citationNeuroscience. Oxford, v. 348, p. 228-240, 2017.
dc.identifier.doi10.1016/j.neuroscience.2017.02.022
dc.identifier.issn0306-4522
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54710
dc.identifier.wosWOS:000398651200021
dc.language.isoeng
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofNeuroscience
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectasphyxiaen
dc.subjectc-Fosen
dc.subjectlaterodorsal tegmental nucleusen
dc.subjectnucleus of the solitary tracten
dc.subjectpanicen
dc.subjectperiaqueductal gray matteren
dc.titleON THE VERGE OF A RESPIRATORY-TYPE PANIC ATTACK: SELECTIVE ACTIVATIONS OF ROSTROLATERAL AND CAUDOVENTROLATERAL PERIAQUEDUCTAL GRAY MATTER FOLLOWING SHORT-LASTING ESCAPE TO A LOW DOSE OF POTASSIUM CYANIDEen
dc.typeinfo:eu-repo/semantics/article
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