Cross-sex testosterone therapy modifies the renal morphology and function in female rats and might underlie increased systolic pressure

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dc.citation.issue48pt_BR
dc.contributor.authorLichtenecker, Debora Conte Kimura [UNIFESP]
dc.contributor.authorRogerio, Argéri
dc.contributor.authorCastro, Charlles Heldan de Moura
dc.contributor.authorDias-da-Silva, Magnus Regios
dc.contributor.authorGomes, Guiomar Nascimento
dc.contributor.authorLatteshttp://lattes.cnpq.br/9515319718254095pt_BR
dc.coverageOxford
dc.date.accessioned2021-08-26T18:25:04Z
dc.date.available2021-08-26T18:25:04Z
dc.date.issued2021-03-12
dc.description.abstractTestosterone esters are hormones commonly used for affirming gender identity in transmen. The present study evaluates the effect of testosterone on renal morphology and function in an animal model submitted to cross-sex hormone therapy used for transmen. Two-month-old Wistar rats were divided into three groups: male control (MC), female control (FC), and female on testosterone therapy (FTT). The FTT group received testosterone cypionate (3.0 mg/kg, i.m.), and the MC and MF groups received vehicle oil every 10 days for 4 months. Renal function and indirect systolic blood pressure (SBP) measurements were evaluated at 6 months of age. Plasma and urine concentrations of urea, creatinine, sodium, potassium, osmolality, and glomerular filtration rate (GFR) were measured. The kidneys were weighed, paraffin-embedded, and histological sections were prepared to evaluate the glomerular area. We verified that the FTT group, in comparison to FC, had increased kidney weight [MC, 3.2 ± 0.05; FC, 1.8 ± 0.04; FTT, 2.2 ± 0.06; g], decreased urine osmolarity [MC, 486.9 ± 18.3; FC, 1012.0 ± 5.4; FTT, 768.2 ± 40.3 mOsm/L/g kw], reduced GFR [MC, 0.77 ± 0.04; FC, 0.78 ± 0.02; FTT, 0.67 ± 0.03; mL/min/g kw], larger glomerular area [MC, 9334 ± 120.8; FC, 7884 ± 112.8; FTT, 9078 ± 133.4 µm2], and higher SBP [MC, 126 ± 3.4; FC, 119 ± 1.0; FTT, 131 ± 1.4; mmHg]. Sodium excretion was higher in FC and FTT in comparison to MC [MC, 0.34 ± 0.05; FC, 0.56 ± 0.06; FTT, 0.54 ± 0.04; mEq/24 h/g kw]. Cross-sex hormone therapy with testosterone in female rats induces renal morphofunctional changes and may underlie increased systolic pressure, suggesting an adaptation similar to what is observed in transmen on long-term testosterone therapy.pt_BR
dc.format.extent978-986
dc.identifierhttps://doi.org/10.1111/1440-1681.13495pt_BR
dc.identifier.citationLICHTENECKER, Débora Conte Kimura et al. Cross-sex testosterone therapy modifies the renal morphology and function in female rats and might underlie increased systolic pressure. Clinical and Experimental Pharmacology & Physiology, Oxford, v. 48, n. 7, p. 978-986, July 2021.
dc.identifier.doihttps://doi.org/10.1111/1440-1681.13495pt_BR
dc.identifier.issn1440-1681
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/61688
dc.languageengpt_BR
dc.publisherBlackwell Scientific Publicationsen
dc.relation.ispartofClinical and Experimental Pharmacology and Physiologypt_BR
dc.rightsinfo:eu-repo/semantics/restrictedAccesspt_BR
dc.subjectBlood pressurept_BR
dc.subjectCross-sex hormone therapypt_BR
dc.subjectGlomerular areapt_BR
dc.subjectRenal function and morphologypt_BR
dc.subjectTestosteronept_BR
dc.subjectTransgenderpt_BR
dc.titleCross-sex testosterone therapy modifies the renal morphology and function in female rats and might underlie increased systolic pressurept_BR
dc.typeinfo:eu-repo/semantics/articlept_BR
unifesp.campusEscola Paulista de Medicina (EPM)pt_BR
unifesp.knowledgeAreaRim e hormôniospt_BR
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