Circulating tumor cell detection during chemotherapy in patients with breast cancer is not associated with plasma homocysteine levels

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dc.contributor.authorYoshihara, Renata Nunes
dc.contributor.authorTeixeira, Bianca Marinelli
dc.contributor.authorAdami, Fernando
dc.contributor.authorKuniyoshi, Renata K.
dc.contributor.authorAlves, Beatriz C. A.
dc.contributor.authorGehrke, Flavia S.
dc.contributor.authorVilas-Boas, Viviane A.
dc.contributor.authorAzzalis, Ligia A. [UNIFESP]
dc.contributor.authorJunqueira, Virginia B. C. [UNIFESP]
dc.contributor.authorPereira, Edimar Cristiano [UNIFESP]
dc.contributor.authorFonseca, Fernando L. A. [UNIFESP]
dc.contributor.institutionABC Med Sch
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:34:29Z
dc.date.available2016-01-24T14:34:29Z
dc.date.issued2013-10-01
dc.description.abstractBreast cancer remains the second most frequent type of cancer in the world and the first among women, and systemic chemotherapy is an adjuvant therapeutic modality that improves survival in a great part of patients. Women with breast cancer, however, frequently show a higher risk of thromboembolism, an event associated to hyperhomocysteinemia and the presence of circulating tumor cells (CTC). Our aim is to correlate the presence of CTCs, detected by the analysis of CK19 and c-erbB2 gene expressions, and the homocysteine plasma levels in the peripheral blood in patients with breast cancer undergoing chemotherapy. Epithelial marker expression (CK19 and c-erbB2) and homocysteine levels were analyzed in a mononuclear fraction of the peripheral blood and plasma, respectively, obtained from 35 patients diagnosed with breast cancer at diagnosis and throughout chemotherapy treatment. No significant relation between the CK19 and c-erbB2 expressions and hyperhomocysteinemia was observed at any moment of the evaluation throughout the chemotherapy treatment (3 and 6 months after the onset). Among clinical data, only menopausal status showed a statistically significant correlation with homocysteine concentration. Although differences in the expressions of the analyzed epithelial markers were detected at 3 and 6 months of chemotherapy treatment, no relation between plasma homocysteine variations and the CK19 and c-erbB2 gene expressions was found in patients under chemotherapy treatment at any moment of the evaluation, suggesting that chemotherapy affects the expressions of the studied genes independently.en
dc.description.affiliationABC Med Sch, Dept Hematol & Oncol, BR-09060650 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Sch Med, BR-01246903 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biol Sci, BR-09972270 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biol Sci, BR-09972270 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipUNIEMP postdoctoral fellowship
dc.description.sponsorshipUNIEMP doctoral fellowship
dc.description.sponsorshipIDFAPESP: 2009/54343-0
dc.description.sponsorshipIDFAPESP: 2009/54342-4
dc.format.extent2937-2941
dc.identifierhttp://dx.doi.org/10.1007/s13277-013-0856-2
dc.identifier.citationTumor Biology. Dordrecht: Springer, v. 34, n. 5, p. 2937-2941, 2013.
dc.identifier.doi10.1007/s13277-013-0856-2
dc.identifier.issn1010-4283
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36804
dc.identifier.wosWOS:000325079200059
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofTumor Biology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectBreast canceren
dc.subjectHomocysteinemiaen
dc.subjectCirculating tumor cellsen
dc.subjectThromboembolismen
dc.subjectEpithelial markersen
dc.titleCirculating tumor cell detection during chemotherapy in patients with breast cancer is not associated with plasma homocysteine levelsen
dc.typeinfo:eu-repo/semantics/article
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