Does Preoperative Electrical Stimulation of the Skin Alter the Healing Process?

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dc.contributor.authorBorba, Graziela Maria Chacon [UNIFESP]
dc.contributor.authorHochman, Bernardo [UNIFESP]
dc.contributor.authorLiebano, Richard E.
dc.contributor.authorEnokihara, Milvia M. S. S. [UNIFESP]
dc.contributor.authorFerreira, Lydia Masako [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv City São Paulo UNICID
dc.date.accessioned2016-01-24T14:06:22Z
dc.date.available2016-01-24T14:06:22Z
dc.date.issued2011-04-01
dc.description.abstractBackground. in vitro studies have demonstrated that electrical current may affect fibroblast proliferation and synthesis of collagen fibers. in humans, the application of electrical current by positioning the positive electrode on skin wounds resulted in thinner hypertrophic scars. the aim of this study was to evaluate the effects of preoperative electrical stimulation on cutaneous wound healing in rats.Materials and Methods. Forty rats were divided into two groups of 20 animals each. in the control group, an incision was made on the back of the animals. in the stimulation group, a preoperative electrical stimulation was applied using a rectangular pulse current at a frequency of 7.7 Hz, and intensity of 8 mA, for 30 min, with the positive electrode placed on the back of the animal, and the negative electrode placed on the abdominal wall. Following, an incision was made on their back. Biopsy was carried out on postoperative day 7 and 14, and histologic analysis was performed.Results. the number of newly formed vessels, fibroblasts, and type III collagen fibers in the stimulation group on postoperative day 7 were greater than those in the control group.Conclusions. Preoperative positive-polarity electrical stimulation positively affects angiogenesis and fibroblast proliferation. (C) 2011 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Disciplina Cirurgia Plast, Dept Surg, BR-04024002 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Dept Pathol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUniv City São Paulo UNICID, Phys Therapy Dept, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Disciplina Cirurgia Plast, Dept Surg, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Dept Pathol, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent324-329
dc.identifierhttp://dx.doi.org/10.1016/j.jss.2009.08.018
dc.identifier.citationJournal of Surgical Research. San Diego: Academic Press Inc Elsevier Science, v. 166, n. 2, p. 324-329, 2011.
dc.identifier.doi10.1016/j.jss.2009.08.018
dc.identifier.issn0022-4804
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33600
dc.identifier.wosWOS:000288168300039
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Surgical Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectelectrical stimulationen
dc.subjecthealing processen
dc.subjectphysiologic neovascularizationen
dc.subjectmast cellen
dc.subjectfibroblasten
dc.subjectcollagenen
dc.subjectskinen
dc.subjectratsen
dc.titleDoes Preoperative Electrical Stimulation of the Skin Alter the Healing Process?en
dc.typeinfo:eu-repo/semantics/article
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