Bioinformatics Approach to BDNF and BDNF-Related Disorders

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dc.contributor.authorDias, Alvaro Machado [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-06-15T17:05:14Z
dc.date.available2018-06-15T17:05:14Z
dc.date.issued2011-06-01
dc.description.abstractContext: Currently, the keyword 'BDNF' retrieves 7388 publications in Pubmed, which point to many directions.Objective: This paper aims to uncover patterns that are hidden under this huge mass of studies and then to review the most prominent sub-topics in 'BDNF and mental health'.Method: Several semi-automatic tools employed, in order to present: 1. A visual representation of BDNF's main molecular pathways; 2. A table with all the components of this pathway that are known to be associated with human diseases; 3. A conceptual map of the whole literature; 4. A histogram of the mental disorders that are known to be associated with BDNF, as well as a review of the literature on each one of these topics.Results: The conceptual map suggests that the field is divided in two major sections: BDNF molecular pathways, receptors, other neurotrophins and neurotransmitters; and BDNF-related disorders. Among the latter, the mental disorders that are mostly related to BDNF are: depression, schizophrenia, Parkinson disease, Alzheimer disease, and bipolar disorder.en
dc.description.affiliationUniv Fed Sao Paulo, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo FMUSP, Inst Psychiat, Dept Neuroimaging Psychiat LIM21, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent318-329
dc.identifierhttp://dx.doi.org/10.2174/157015911795596586
dc.identifier.citationCurrent Neuropharmacology. Sharjah: Bentham Science Publ Ltd, v. 9, n. 2, p. 318-329, 2011.
dc.identifier.doi10.2174/157015911795596586
dc.identifier.issn1570-159X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43459
dc.identifier.wosWOS:000295409600006
dc.language.isoeng
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCurrent Neuropharmacology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectBDNFen
dc.subjectgenetic neuroscienceen
dc.subjectbioinformaticsen
dc.subjectdata miningen
dc.subjectreviewen
dc.titleBioinformatics Approach to BDNF and BDNF-Related Disordersen
dc.typeinfo:eu-repo/semantics/article
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