Airway-centered interstitial fibrosis: etiology, clinical findings and prognosis

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dc.contributor.authorKuranishi, Lilian Tiemi [UNIFESP]
dc.contributor.authorLeslie, Kevin O.
dc.contributor.authorFerreira, Rimarcs Gomes [UNIFESP]
dc.contributor.authorColetta, Ester Aparecida Ney [UNIFESP]
dc.contributor.authorStorrer, Karin Mueller [UNIFESP]
dc.contributor.authorSoares, Maria Raquel [UNIFESP]
dc.contributor.authorPereira, Carlos Alberto de Castro [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionMayo Clin
dc.date.accessioned2016-01-24T14:40:30Z
dc.date.available2016-01-24T14:40:30Z
dc.date.issued2015-05-09
dc.description.abstractBackground: Airway-centered Interstitial Fibrosis (ACIF) is a common pathologic pattern observed in our practice.Objectives: the objectives of this study are to describe the causes associated with ACIF in a large sample of patients and its effect on survival.Methods: A retrospective study in three centers of interstitial lung disease in São Paulo, between January of 1995 and December of 2012. the surgical lung biopsy specimens were reviewed by three pathologists. the clinical, functional and tomographic findings were analyzed by a standardized protocol.Results: There were 68 cases of ACIF, most of them women. the mean age was 57 +/- 12 yr. Dyspnea, cough, restrictive pattern at spirometry and oxygen desaturation at exercise were common. A reticular pattern with peribronchovascular infiltrates was found in 79% of the cases. the etiologies of ACIF were hypersensitivity pneumonitis in 29 (42.6%), gastroesophageal reflux disease in 17 (25.0%), collagen vascular disease in 4 (5.9%), a combination of them in 15 cases and idiopathic in 3 (4.4%). the median survival was 116 months (95% CI = 58.5 - 173.5). Lower values of oxygen saturation at rest, presence of cough and some histological findings - organizing tissue in the airways, fibroblastic foci and microscopic honeycombing - were predictors of worse survival.Conclusions: ACIF is an interstitial lung disease with a better survival when compared with IPF. the main etiologies are HP and GERD. the oxygen saturation at rest, the presence of cough and some histological findings are predictors of survival.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pulm, São Paulo, Brazil
dc.description.affiliationMayo Clin, Dept Pathol, Scottsdale, AZ USA
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pulm, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pathol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent8
dc.identifierhttp://dx.doi.org/10.1186/s12931-015-0213-7
dc.identifier.citationRespiratory Research. London: Biomed Central Ltd, v. 16, 8 p., 2015.
dc.identifier.doi10.1186/s12931-015-0213-7
dc.identifier.fileWOS000354247000001.pdf
dc.identifier.issn1465-993X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/39098
dc.identifier.wosWOS:000354247000001
dc.language.isoeng
dc.publisherBiomed Central Ltd
dc.relation.ispartofRespiratory Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectInterstitial lung diseaseen
dc.subjectHypersensitivity pneumoniaen
dc.subjectGastroesophageal refluxen
dc.subjectPulmonary fibrosisen
dc.titleAirway-centered interstitial fibrosis: etiology, clinical findings and prognosisen
dc.typeinfo:eu-repo/semantics/article
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