Imipenem-resistant Pseudomonas aeruginosa infection at a medical-surgical intensive care unit: Risk factors and mortality

Página do item simplificado
dc.contributor.authorFurtado, Guilherme H. C. [UNIFESP]
dc.contributor.authorBergamasco, Maria D. [UNIFESP]
dc.contributor.authorMenezes, Fernando G. [UNIFESP]
dc.contributor.authorMarques, Daniel [UNIFESP]
dc.contributor.authorSilva, Adriana [UNIFESP]
dc.contributor.authorPerdiz, Luciana B. [UNIFESP]
dc.contributor.authorWey, Sergio B. [UNIFESP]
dc.contributor.authorMedeiros, Eduardo A. S. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:58:58Z
dc.date.available2016-01-24T13:58:58Z
dc.date.issued2009-12-01
dc.description.abstractObjectives: the aim of this study was to evaluate the risk factors and attributable mortality associated with imipenem-resistant Pseudomonas aeruginosa (IRPA) infections in a medical-surgical intensive care unit (ICU).Methods: A retrospective case-control study was carried out at a 16-bed medical-surgical ICU in a 780-bed, university-affiliated hospital. All patients admitted from January 1, 2003, to December 31, 2004, who had nosocomial infection caused by IRPA, were included in the study.Results: Imipenem-resistant P. aeruginosa was recovered from 63 patients during the study period. One hundred eighty-two controls were matched with cases by period of admission, age, and time at risk. Urinary tract (34.9%) and respiratory tract (22.2%) were the main sources of IRPA isolation. in multivariate analysis, a previous stay in the ICU (odds ratio, 3.54; 95% confidence interval [CI], 1.29-9.73; P = .03) was the only independent risk factor for IRPA infection. the in-hospital mortality rate among case patients was 49% (31 of 63) compared with 33% (61 of 182) for control patients (odds ratio, 1.92; 95% CI, 1.07-3.44; P = .02). Thus, we had an attributable mortality of 16% (95% CI, 9.74%-22.3%; P = .03).Conclusions: Our study suggests that IRPA infections are strongly related to previous ICU stay, and that IRPA infections significantly increase mortality in those critical patients. (C) 2009 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Hosp Epidemiol Comm, Div Infect Dis, BR-04037004 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Hosp Epidemiol Comm, Div Infect Dis, BR-04037004 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent6
dc.identifierhttp://dx.doi.org/10.1016/j.jcrc.2009.03.006
dc.identifier.citationJournal of Critical Care. Philadelphia: W B Saunders Co-Elsevier Inc, v. 24, n. 4, 6 p., 2009.
dc.identifier.doi10.1016/j.jcrc.2009.03.006
dc.identifier.issn0883-9441
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31993
dc.identifier.wosWOS:000283717200002
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Critical Care
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectPseudomonas aeruginosaen
dc.subjectImipenem resistanceen
dc.subjectNosocomial infectionen
dc.subjectRisk factorsen
dc.subjectMortalityen
dc.subjectIntensive care uniten
dc.titleImipenem-resistant Pseudomonas aeruginosa infection at a medical-surgical intensive care unit: Risk factors and mortalityen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos