The effect of macadamia oil intake on muscular inflammation and oxidative profile kinetics after exhaustive exercise

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dc.contributor.authorMalvestiti, Rosane
dc.contributor.authorBorges, Leandro da Silva
dc.contributor.authorWeimann, Eleine
dc.contributor.authorda Silva Junior, Edenilson Pinto
dc.contributor.authorLevada-Pires, Adriana Cristina
dc.contributor.authorDermargos, Alexandre
dc.contributor.authorLambertucci, Rafael Herling [UNIFESP]
dc.contributor.authorHatanaka, Elaine
dc.date.accessioned2019-08-19T11:50:05Z
dc.date.available2019-08-19T11:50:05Z
dc.date.issued2017
dc.description.abstractIn this study, we evaluated the onset and resolution of inflammation in control and macadamia oil-supplemented rats after a single session of exhaustive exercise. We also analysed the antioxidant enzymes catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), and thiobarbituric acid reactive substances (TBARS). Rats were supplemented for ten days with macadamia oil (25 mg/kg), which is rich in oleic and palmitoleic acids. On the 10th day, control and macadamia oil-treated rats exercised to physical exhaustion. Plasma and muscular levels of pro-inflammatory cytokines (tumour necrosis factor alpha [TNF-], interleukin-1 beta [IL-1], IL-6, cytokine-induced neutrophil chemoattractant-3 [CINC-3], macrophage inflammatory protein-3-alpha [MIP-3]) and soluble L-selectin were measured prior to, immediately after, and 2, 24, and 48 h after exercise. Our data revealed increases in the muscle concentrations of IL-1, L-selectin, CINC-3, and MIP-3 in the group supplemented with macadamia oil compared with the concentrations in the control group. CAT also increased in the treated group, which is important because pro-inflammatory cytokines precede growth factor production and might alter the muscle repair process. We concluded that inflammation resulting from exhaustive exercise was greater in animals that received macadamia oil than in control animals. Practical applications: There are potential benefits of using fatty acids in the treatment of injured muscles, and these substances have been used in several types of injured tissues. Macadamia oil intake alters muscle healing signaling by influencing the production of reactive oxygen species and inflammatory mediators. Therefore, it is reasonable to hypothesize that the intake of immunomodulatory supplements would be beneficial to the muscular recovery of an athlete following a strenuous exercise session.en
dc.description.affiliationCruzeiro do Sul Univ, Inst Phys Act & Sport Sci, Rua Galvao Bueno 868,13 Andar, BR-01506000 São Paulo, SP, Brazil
dc.description.affiliationUniv Paulista UNIP, Manaus, Amazonas, Brazil
dc.description.affiliationUniv Fed São Paulo UNIFESP, Dept Biociencias, São Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed São Paulo UNIFESP, Dept Biociencias, São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo a Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIDFAPESP: 14/03947-1
dc.description.sponsorshipIDCNPq: 307769/2014-3
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1002/ejlt.201600382
dc.identifier.citationEuropean Journal Of Lipid Science And Technology. Hoboken, v. 119, n. 8, p. -, 2017.
dc.identifier.doi10.1002/ejlt.201600382
dc.identifier.issn1438-7697
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/51472
dc.identifier.wosWOS:000407162500011
dc.language.isoeng
dc.publisherWiley
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectCytokinesen
dc.subjectInflammationen
dc.subjectMuscleen
dc.subjectPhysical activityen
dc.subjectTNF-en
dc.subjectIL-1en
dc.titleThe effect of macadamia oil intake on muscular inflammation and oxidative profile kinetics after exhaustive exerciseen
dc.typeinfo:eu-repo/semantics/article
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